Thyroid Diseases: Buchinger W

Bieglmayer C, Buchinger W, Födinger M, Müller MM, Sinha P, Vogl M, Weissel M, Zechmann W. · Osterreichische Gesellschaft für Laboratoriumsmedizin und Klinische Chemie, Wien, Austria. · Wien Klin Wochenschr. · Pubmed #18709526 No free full text.

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Niederwieser G, Buchinger W, Bonelli RM, Berghold A, Reisecker F, Költringer P, Archelos JJ. · Department of Neurology, Barmherzige Brüder Hospital, Bergstrasse 27, 8021 Graz, Austria. · J Neurol. · Pubmed #12796827 No free full text.

Abstract: Since multiple sclerosis (MS) and autoimmune thyroiditis (AIT) are presumed to be of autoimmune origin the correlation of these two diseases is of special interest. The aim of this study was to determine whether there are differences in the prevalence of thyroid disease with special emphasis on AIT compared with MS and normal subjects and whether the presence of thyroid disease correlates with disability, disease course, age, and disease duration. 353 consecutive patients with clinically definite MS, without interferon-beta treatment and 308 patients with low back pain or headache were extensively examined for the presence of non-immune or autoimmune thyroid disease. We found a significantly higher prevalence of AIT in male MS patients (9.4 %) than in male controls (1.9 %; p = 0.03). The prevalence of AIT in female MS patients (8.7 %) did not differ from female controls (9.2 %). Hypothyroidism, caused by AIT in almost all cases, showed a tendency to be more severe and more often present in patients with MS. There was no association between relapsing-remitting and secondary progressive disease course of MS and the prevalence of AIT. MS patients with AIT were significantly older but did not differ in disease duration and expanded disability status scale (EDSS). Further studies are warranted, to see if there is a difference in sex-hormone levels between MS patients with and without AIT and healthy controls. Longitudinal studies comparing MS patients with or without AIT could show whether there is an influence of AIT on the disease course or progression.

Pongratz R, Buchinger W, Semlitsch G, Meister E, Nadler K, Rainer F. · Internen Abteilung des Krankenhauses der Barmherzigen Brüder, Eggenberg, Graz. · Acta Med Austriaca. · Pubmed #10812469 No free full text.

Abstract: The frequent occurrence of both rheumatoid arthritis and autoimmune thyroiditis was already investigated with in part many conflicting results. We investigated a number of 792 patients (383 of them suffering from rheumatoid arthritis and 409 with osteoarthritis). In all patients antithyroid peroxidase and antithyroglobulin antibodies were determined. Patients with rheumatoid arthritis showed a significantly higher occurrence of circulating thyroid antibodies than those with osteoarthritis (9.1% versus 3.7%, p = 0.0016). We conclude that there exists a cumulate coincidence of both diseases. Patients suffering from rheumatoid arthritis should undergo a thyroid examination especially for the presence of autoimmune thyroiditis.

Semlitsch G, Buchinger W, Reiterer E, Binter G, Rainer F. · Abteilung für Innere Medizin und Nuklearmedizin des Krankenhauses der Barmherzigen Brüder Graz-Eggenberg. · Acta Med Austriaca. · Pubmed #10812467 No free full text.

Abstract: Thyroid hormone autoantibodies may lead to abnormal values of free triiodothyronine (FT3) and free thyroxine (FT4) by interference with the radio immunoassay (RIA). We examined thyroid function in six patients with known triiodothyronine-binding autoantibodies using a RIA and an electro-chemiluminescence immunoassay (ECLIA). FT3 values measured by RIA were spuriously high, ECLIA measurement of FT3 led to correct values according to the patients' thyroid status. We conclude from these results that in patients with triiodothyronine-binding autoantibodies FT3 measurement by ECLIA is more useful than measurement by RIA.

Buchinger W, Semlitsch G, Pongratz R, Harwalik B, Rainer F. · Schilddrüsenambulanz der Internen Abteilung des Krankenhauses, Barmherzigen Brüder, Graz-Eggenberg. · Acta Med Austriaca. · Pubmed #10812466 No free full text.

Abstract: Seasonal variations in the frequency of thyrotoxicosis are known for a long time. Both, variations in the temperature and in the iodine supplementation are believed to affect the incidence of the diagnosis of hyperthyroidism. Seasonal variation of the incidence of hyperthyroidism was investigated before and after increase of salt iodination in 1990/1991. In the period from January 1987 to December 1995 hyperthyroidism was diagnosed for the first time on 4711 patients in our department. This population was subdivided according to etiology (Graves' disease, autonomous nodular goiter) and grade of hyperthyroidism (preclinical or clinical form). The so formed groups were divided according to the month of diagnosis into further 12 subgroups. Significant differences in month to month variation were found in the patients suffering from Graves' disease and autonomous nodular goiter with preclinical hyperthyroidism after increased iodine supplementation. The peak incidence of the diagnosis occurred in June, July, and August. Our results indicate that improved iodine supplementation may be the main cause of seasonal variations in the incidence of thyrotoxicosis.

Buchinger W, Niederwieser G, Rainer F. · No affiliation provided · Dtsch Med Wochenschr. · Pubmed #10615332 No free full text.

This publication has no abstract.