Stiff-Person Syndrome

Overview

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Is a:

Disease or Syndrome

Definition:

A condition characterized by persistent spasms (spasm) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)

Synonyms:

Moersch Woltmann Syndrome
Moersch-Woltmann Syndrome
Stiff Man Syndrome
Stiff Person Syndrome
Stiff-Man Syndrome
Stiffman Syndrome
Syndrome, Moersch-Woltmann
Syndrome, Stiff-Man
Syndrome, Stiff-Person
Syndrome, Stiffman

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