Sleep Apnea Syndromes: Hohenhorst W

Verse T, de la Chaux R, Dreher A, Fischer Y, Grundmann T, Hecksteden K, Hörmann K, Hohenhorst W, Ilgen F, Kühnel T, Mahl N, Maurer JT, Pirsig W, Roth B, Siegert R, Stuck BA, Anonymous00280. · Klinik für HNO-Heilkunde, Asklepios Klinik Harburg, Hamburg. · Laryngorhinootologie. · Pubmed #17464894 No free full text.

This publication has no abstract.

Stoohs RA, Knaack L, Blum HC, Janicki J, Hohenhorst W. · Somnolab - Dortmund Sleep Disorders Center, Hörder Burgstr. 18, 44263 Dortmund, Germany. · Sleep Med. · Pubmed #17644425 No free full text.

Abstract: BACKGROUND: The clinical features of patients with upper airway resistance syndrome (UARS) have previously been compared to patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). No data regarding differences between patients with primary snoring (PS) or patients with obstructive sleep apnea/hypopnea without daytime sleepiness (OSAH) are available. We conducted a study to investigate clinical features of UARS, comparing them to those in patients with PS, OSAH, and OSAHS. METHODS: Retrospective chart analysis of 157 patients with PS, 424 patients with UARS, 562 patients with OSAH, and 1610 patients with OSAHS seen in two sleep disorders clinics between 1996 and 2006. All patients had a diagnostic polysomnography (PSG) and a comprehensive clinical history taken by board-certified sleep specialists. RESULTS: PS and UARS patients were significantly younger, less overweight and had lower weight gain during the past 5years. The female-to-male ratio was highest in the UARS group. UARS patients had significantly less stage non-rapid eye movement sleep (NREM) 1 and NREM 2 and significantly more NREM 3 and NREM 4 sleep than OSAH and OSAHS patients. Arousal indices between PS/UARS and OSAH/OSAHS patients were significantly lower, with no significant difference within these diagnostic categories. Patients with UARS presented the highest degree of subjective impairment. CONCLUSIONS: UARS patients share some clinical features of patients with OSAHS and PS, although these two groups differ in their presentation of clinical sleepiness. Patients with UARS were most impaired in terms of their daily functioning and perception of sleep quality. This finding could not be corroborated by objective measures.

Stoohs R, Janicki J, Hohenhorst W. · Somnolab-Zentrum für Schlafmedizin, Christian Guilleminault Schlaflabor, 44263, Dortmund. · HNO. · Pubmed #17287938 No free full text.

Abstract: BACKGROUND: The aim of this study was to assess potential gender-related differences in the clinical presentation and polysomnographic parameters of patients with obstructive sleep apnea syndrome (OSAS) and upper airway resistance syndrome (UARS). PATIENTS AND METHODS: The polysomnographic variables and medical histories of 165 women with OSAS and 66 women with UARS from two sleep disorder clinics, presenting consecutively between 2000 and 2006 were retrospectively analyzed. These women were matched with an identical number of men, presenting during the same time frame, by diagnostic category (UARS/OSAS), age, and BMI. RESULTS: The relative percentage of women diagnosed with UARS varied dependent on their menopausal status. Postmenopausal women presented significantly less frequently with UARS than pre- and perimenopausal women. The adjusted odds ratio for a diagnosis of OSAS vs UARS was 5.5 (CI: 2.3;13.2; P=0.001) compared to premenopausal women. UARS women had a 30 min higher subjective sleep need than UARS men (8.2+/-1.1 vs 7.7+/-1.1 h/night; P=0.028). UARS women consumed significantly more prescription drugs than UARS men (P=0.017), and presented with a significantly lower quality of life score than their male counterparts (P=0.021). The quantitative snoring measure during sleep did not indicate significant gender differences between diagnostic categories and gender. CONCLUSIONS: Clinical presentation and polysomnographic parameters in patients with OSAS and UARS show distinct gender-related differences. These differences should be considered when patients present with signs and symptoms of OSAS or UARS.