Sleep Apnea Syndromes: Bray GA

Klein S, Burke LE, Bray GA, Blair S, Allison DB, Pi-Sunyer X, Hong Y, Eckel RH, Anonymous00031. · No affiliation provided · Circulation. · Pubmed #15509809 links to  free full text

Abstract: Obesity adversely affects cardiac function, increases the risk factors for coronary heart disease, and is an independent risk factor for cardiovascular disease. The risk of developing coronary heart disease is directly related to the concomitant burden of obesity-related risk factors. Modest weight loss can improve diastolic function and affect the entire cluster of coronary heart disease risk factors simultaneously. This statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism reviews the relationship between obesity and the cardiovascular system, evaluates the effect of weight loss on coronary heart disease risk factors and coronary heart disease, and provides practical weight management treatment guidelines for cardiovascular healthcare professionals. The data demonstrate that weight loss and physical activity can prevent and treat obesity-related coronary heart disease risk factors and should be considered a primary therapy for obese patients with cardiovascular disease.

Bray GA, Bellanger T. · Pennington Biomedical Research Center, Baton Rouge, LA, USA. · Endocrine. · Pubmed #16622298 No free full text.

Abstract: Obesity has been described as an epidemic because of the rapid increase in the number of overweight and obese individuals over the past 20 yr. This increasing prevalence of obesity is a worldwide phenomenon affecting both children and adults. The metabolic syndrome is a constellation of central adiposity, impaired fasting glucose, elevated blood pressure, and dyslipidemia (high triglyceride and low HDL cholesterol). When three of these five criteria are present, the risk of cardiovascular disease and diabetes is increased 1.5- to 2-fold. As body weight, expressed as the BMI, rises, there are a number of other diseases that are associated with it. First, life span is shortened and the risk of sudden death increases. Second, the risk of diabetes, gall bladder disease, hypertension, heart disease, osteoarthritis, sleep apnea, and certain forms of cancer also increase.

Bellanger TM, Bray GA. · Department of Internal Medicine, Louisiana State University Health Sciences Center, Baton Rouge, Louisiana, USA. · J La State Med Soc. · Pubmed #15751909 No free full text.

Abstract: The epidemic of obesity has highlighted the extent of the risks associated with this disease. The risks arise from the increased mass of fat tissue, as well as the products produced by the increased number and size of fat cells in obese individuals. Psychosocial dysfunction, obstructive sleep apnea, and osteoarthritis can be a direct result of increased fat mass. Other diseases associated with obesity result from the metabolic consequences of enlarged fat cells. Diabetes, gallbladder stones, high blood pressure, liver disease, coronary artery disease, cerebrovascular disease, certain types of cancers, and infertility can all be traced in part to the increased secretion of inflammatory and coagulation molecules from fat cells. Finally, obesity also increases overall mortality. It is clear from this review that the morbidity and increased mortality of overweight and obesity is substantial and should prompt further attention towards the need for appropriate weight management in health care.

Caterson ID, Hubbard V, Bray GA, Grunstein R, Hansen BC, Hong Y, Labarthe D, Seidell JC, Smith SC, Anonymous00034. · No affiliation provided · Circulation. · Pubmed #15520332 links to  free full text

This publication has no abstract.