Psoriasis: Weisenseel P

Weisenseel P, Kuznetsov AV, Prinz JC. · Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, München, Germany. · J Dtsch Dermatol Ges. · Pubmed #17659043 No free full text.

Abstract: The recently published German S3- guidelines for the treatment of psoriasis vulgaris offer an extensive evidence-based documentation and evaluation of currently available treatment modalities. In order to incorporate this detailed information into the actual treatment decisions in individual patients, we have transformed the recommendations regarding phototherapy and systemic therapies into an algorithm. This algorithm should allow a stepwise treatment approach in adult patients with moderate to severe psoriasis, in whom topical therapy is not sufficient. It can also facilitate documentation of treatment. In our hands the treatment algorithm proved to be feasible and reliable in a large number of patients.

Weisenseel P, Kuznetsov AV, Flaig M, Prinz JC. · Department of Dermatology, Ludwig Maximilian University, Munich, Germany. · Dermatology. · Pubmed #18446030 No free full text.

Abstract: Molluscum contagiosum is a common viral skin infection in children with atopic diathesis and not rare in HIV patients. We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.

Weisenseel P, Prinz JC. · Department of Dermatology, Ludwig-Maximilians-University, Munich, Germany. · Cutis. · Pubmed #17036664 No free full text.

Abstract: Generalized pustular psoriasis is a dramatic potentially life-threatening psoriasis variant and represents a major therapeutic challenge. Tumor necrosis factor alpha (TNF-alpha) inhibitors have been shown to be highly effective in psoriasis vulgaris and psoriasis arthritis. Currently, TNF-alpha can be targeted therapeutically by 2 different approaches. TNF-alpha antibodies show a fast onset of action and a long-lasting activity. Soluble TNF-alpha receptors have a slower onset and a shorter duration of activity, which allows a rapid cessation of the drug's activity in the case of adverse events. Here we report that a remission of generalized pustular psoriasis achieved by the TNF-alpha antibody infliximab was maintained by long-term application of the soluble TNF-alpha receptor etanercept. Sequential therapy with TNF-alpha antibodies and TNF-alpha receptors may represent a novel concept that combines a rapid onset of action in the initiation therapy with a lower risk for severe adverse events in the maintenance treatment of pustular psoriasis.

Weisenseel P, Prinz JC. · Department for Dermatology, Ludwig Maximilians-University, Frauenlobstr. 9-11, 80337, Munich, Germany. · Arch Dermatol Res. · Pubmed #15856267 No free full text.

Abstract: Psoriasis vulgaris is a T cell-mediated autoimmune skin disease. First disease onset and disease worsening are often triggered by tonsillar infection with Streptococcus pyogenes. Here we demonstrate the incidental detection of S. pyogenes DNA in samples of different biological origin from patients with chronic plaque-type psoriasis by PCR. These findings may support the model of molecular mimicry in psoriasis pathogenesis.

Weisenseel P, Laumbacher B, Besgen P, Ludolph-Hauser D, Herzinger T, Roecken M, Wank R, Prinz JC. · No affiliation provided · J Med Genet. · Pubmed #12362037 links to  free full text

This publication has no abstract.

Weisenseel P, Kuznetsov AV, Ruzicka T, Prinz JC. · No affiliation provided · Br J Dermatol. · Pubmed #17535244 No free full text.

This publication has no abstract.