Parkinson Disease: Mano Y

Miziuno Y, Okuma Y, Kikuchi S, Kuno S, Hashimoto T, Hasegawa K, Mano Y, Miwa H, Murata M, Yamamoto M, Yokochi F, Okiyama R, Kanazawa A, Shinpo K, Chuma T, Higashi T, Maruyama T, Mizuta E, Yamazaki S, Anonymous00188. · Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan · Rinsho Shinkeigaku. · Pubmed #12708433 No free full text.

This publication has no abstract.

Mano Y. · No affiliation provided · Nippon Naika Gakkai Zasshi. · Pubmed #12710061 No free full text.

This publication has no abstract.

Chuma T, Faruque Reza M, Ikoma K, Mano Y. · Department of Rehabilitation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. · J Neural Transm. · Pubmed #15959849 No free full text.

Abstract: In the present research, changes in motor cortex function were observed in relation to repetitive, voluntary thumb movement (training) in patients with Parkinson's disease (PD) and normal control subjects. Changes in the direction of thumb movement due to motor evoked potential (MEP) by transcranial magnetic stimulation (TMS), after motor training with and without rhythmic sound, were measured using a strain gauge for 12 patients with PD and 9 normal control subjects. PD patients who experienced the freezing phenomena showed poor change in direction of TMS-induced movement after self-paced movement; however, marked change in direction of TMS-induced movement was observed after training with auditory cue. PD patients who had not experienced the freezing phenomena showed positive effects with the auditory cue, producing similar results as the normal control subjects. Two routes for voluntary movement are available in the nervous system. The decreased function of basal ganglia due to PD impaired the route from the basal ganglia to the supplementary motor cortex. These data suggest that the route from sensory input to cerebellum to premotor cortex could compensate for the decreased function of the route via the basal ganglia to the premotor cortex. Once change in the motor cortex occurred, such change persisted even after the interruption of training. These phenomena suggest that motor memory can be stored in the motor cortex.

Tsuchida T, Mano Y. · Hokkaido University, Graduate School of Medicine. · Nippon Ronen Igakkai Zasshi. · Pubmed #12822469 links to  free full text

Abstract: We surveyed patients with Parkinson's disease living at home and elderly persons in hospital to find out causes of falls. In Parkinson's disease, the number of falls during the previous year increased with the progress of the grade of Hoehn and Yahr stage. The ratio of patients who had fractures due to falls was 0% in stage I & II, 30.2% in stage III, and 36.1% in stage IV. The ratio of patients who attached handrails was 30.1% in Hoehn and Yahr stage III, and 37.1% in stage IV; remodeling of hte bathroom was done in 30.7% and 51.0% remodeling of the laboratory was done in 42.5% and 53.8%, and bed adjustment in 24.3% and 43.8%. To prevent falls, we should advise patients to arrange the surroundings in which they spend the daytime such as their living room or bedroom. From the result of the ratios of patients in hospital who had falls and fractures due to falls, some associated risk factors of falls which could be prevented were found out. The ratio of patients who fell in the morning was reduced by interventions of nurses. The frequency of patients who fell was 41.5% in cerebrovascular disease, 29.5% in dementia, 11.2% in bone and joint disease, and 9.0% in Parkinson's disease, however the frequency in hospitalized patients was 56.9%, 11.3%, 7.3%, 6.3% respectively. Patients who had dementia had a tendency to fall. Further study is needed to help prevent of falls in dementia patients.