Parkinson Disease: Kolchinsky AM

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A digest of articles written 1999 and later, on the topic "Parkinson Disease," originating from Planet Earth —» Kolchinsky AM.  Display:  All Citations ·  All Abstracts
1 Review Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease. 2008

Kazantsev AG, Kolchinsky AM. · Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Bldg 114, 3300 16th St, Charlestown, MA 02129-4404, USA. · Arch Neurol. · Pubmed #19064744 No free full text.

Abstract: Selective death of nigrostriatal neurons, which leads to Parkinson disease, is explained by misfolding of brain protein alpha-synuclein. Herein, we review the data supporting this concept, propose a scheme of events leading to synuclein-induced neuronal death, and discuss protein deacetylase sirtuins as new potential therapeutic targets involved in this process.