Parkinson Disease: Esper CD

Esper CD, Weiner WJ, Factor SA. · Department of Neurology Emory University School of Medicine, Atlanta, GA, USA. · Rev Neurol Dis. · Pubmed #18195676 No free full text.

Abstract: Since progressive supranuclear palsy (PSP) was first reported as a separate clinicopathological entity in 1964, hundreds of other cases have been recorded, and PSP is now one of the most common atypical Parkinson-plus disorders. Diagnostic criteria have been developed by the National Institute of Neurological Disorders and Stroke and the Society for PSP, Inc. Because there is no biological marker for PSP, definitive diagnosis depends on neuropathological examination. Characteristics of PSP include gait disturbances, supranuclear ophthalmoplegia, axial limb rigidity, and frontal lobe dysfunction. Although there are no treatments that alter the natural history of disease in PSP and no drugs that provide significant symptomatic benefits, several supportive measures are available.

Esper CD, Factor SA. · Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30329, USA. · Mov Disord. · Pubmed #18067180 No free full text.

Abstract: Our objective was to evaluate the ability of neurologists to recognize and diagnose drug-induced Parkinsonism (DIP) in the elderly. DIP is a diagnostic challenge because it can be indistinguishable from Parkinson's disease, especially in the elderly. It is frequently under-recognized by psychiatrists and primary care physicians. Atypical antipsychotics (AA) are advertised for their low propensity to cause DIP. This may add to problems with recognition. We performed a retrospective record review of consecutive new parkinsonian patients seen over 2 years in a movement disorders clinic to examine the frequency, causative agents, and diagnostic accuracy of DIP by physicians, particularly neurologists. Of 354 Parkinsonian patients evaluated, 24 (6.8%) had DIP, 46% of these were due to AA and 29% were caused by metoclopramide. Of the 24 patients with DIP, only one was previously diagnosed accurately according to records. Nineteen patients (79%) were previously evaluated by a neurologist, and none of them was diagnosed with DIP. The primary reason for failure to recognize DIP relates to under-recognition of AA as possible cause. A majority remained on the inciting agents while dopaminergic drugs were prescribed. DIP was reversible when the inciting drug was stopped. DIP is a common form of parkinsonism and is under-recognized, even by neurologists. AA and metoclopramide do not appear to be well-known to cause DIP. Cessation of the offending agent results in improvement of symptoms and would eliminate the need for dopaminergic agents, which are known to commonly cause side effects in the elderly.