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Review Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. 2008
Devine MJ, Lewis PA. · Department of Clinical Neuroscience, Imperial College London, UK. · FEBS J. · Pubmed #19021752 No free full text.
Abstract: The last decade has seen clear links emerge between the genetic determinants and neuropathological hallmarks of parkinsonism and dementia, notably with the discovery of mutations in alpha-synuclein and tau. Following the description of mutations in LRRK2 linked to Parkinson's disease, characterized by variable pathology including either alpha-synuclein or tau deposition, it has been suggested that LRRK2 functions as an upstream regulator of Parkinson's disease pathogenesis. This minireview explores this model, in the context of our current understanding of the biochemistry of LRRK2, alpha-synuclein and tau.
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