Parkinson Disease: Cozzens JW

Cozzens JW. · Northwestern University Feinberg School of Medicine, Movement Disorders Functional Neurosurgical Program, Evanston Northwestern Healthcare, Illinois, USA. · Dis Mon. · Pubmed #17586330 No free full text.

This publication has no abstract.

Novak KE, Nenonene EK, Bernstein LP, Vergenz S, Medalle G, Prager JM, Eller TW, Cozzens JW, Rezak M. · Department of Neurology, at Evanston Northwestern Healthcare, Evanston, Illinois, USA. · Mov Disord. · Pubmed #16721751 No free full text.

Abstract: Deep brain stimulation is generally a safe and effective method of alleviating motor impairment in advanced-stage Parkinson's disease patients. However, adverse events of surgery have been noted, such as hemorrhage, infection, seizures, and device failure. In this report, we describe 2 cases of the unusual adverse event of ischemia associated with subthalamic nucleus stimulator implantation. We present the intraoperative neurological symptoms, microelectrode recording data, imaging findings, and other correlated events. In the first case, the clinical effects of ischemia were evident intraoperatively and coincided with silence during microelectrode recording from the ischemic region. In the second case, the timing of the ischemic event could not be determined precisely but also was associated with a difficult mapping. Subcortical ischemia may be an underrecognized event that confounds neurophysiological mapping of deep brain structures and affects clinical outcomes.