Paraneoplastic Cerebellar Degeneration

Overview

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Is a:

Disease or Syndrome

Definition:

Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and gait ataxia; dysarthria; and nystagmus, pathologic. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)

Synonyms:

Anti Yo Associated Paraneoplastic Cerebellar Degeneration
Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration
Cerebellar Degeneration, Paraneoplastic
Cerebellar Syndrome, Paraneoplastic
Cerebellar Syndromes, Paraneoplastic
Degeneration, Paraneoplastic Cerebellar
Paraneoplastic Cerebellar Degeneration, Anti Yo Associated
Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated
Paraneoplastic Cerebellar Syndrome
Paraneoplastic Cerebellar Syndromes

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