Apparent Mineralocorticoid Excess Syndrome

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Is a:
  • Disease or Syndrome
Definition:
A hereditary disease characterized by childhood onset hypertension, hypokalemic alkalosis, and low renin and aldosterone secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID dehydrogenase type 2 enzyme which results in inadequate conversion of cortisol to cortisone. The build up of unprocessed cortisol to levels that stimulate mineralocorticoid receptors creates the appearance of having excessive mineralocorticoids.
Synonyms:
  • Apparent Mineralocorticoid Excess Syndrome
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Narrower Topics:
  • None
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