Melanoma: Salomao D

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A digest of articles written 1999 and later, on the topic "Melanoma," originating from Planet Earth —» Salomao D.  Display:  All Citations ·  All Abstracts
1 Guideline Recommendations for the reporting of tissues removed as part of the surgical treatment of common malignancies of the eye and its adnexa. The Association of Directors of Anatomic and Surgical Pathology. 2003

Folberg R, Salomao D, Grossniklaus HE, Proia AD, Rao NA, Cameron JD, Anonymous00355. · Department of Ophthalmology at the University of Illinois at Chicago, 60612, USA. · Hum Pathol. · Pubmed #12612878 No free full text.

This publication has no abstract.

2 Article Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients. 2002

Strome SE, Martin E, Flies D, Khurana D, Salomao D, Tamada K, Chapoval AI, Kasperbauer JL, Olsen KD, Chen L. · Department of Otorhinolaryngology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA. · Otolaryngol Head Neck Surg. · Pubmed #11870350 No free full text.

Abstract: OBJECTIVES: CD62L was evaluated as a determinant of human pre-effector T cells. STUDY DESIGN AND SETTING: Phenotype and cytokine secretion profiles of CD62L cells were determined based on activation status. RESULTS: CD62L(Low) T cells demonstrated significantly higher secretion of interleukin (IL)-10 and interferon (IFN)-gamma than did CD62L(High) T cells. After activation, the majority of cells expressed high levels of the CD62L surface marker. Postactivation levels of IL-10 production remained elevated or unchanged. In a murine B16 melanoma model, freshly isolated CD62L(Low) tumor draining lymph nodes (TDLN) T cells showed increased secretion of IL-2 and IL-4 but not of IL-10 or IFN-gamma. The surface expression of CD62L and cytokine secretion patterns were maintained after activation with concomitant increases in IL-10. CONCLUSION: Our results provide evidence that CD62L(Low) T cells in TDLNs of progressively growing squamous cell carcinoma of the head and neck differ phenotypically and functionally from those of mouse origin. SIGNIFICANCE: Characterization of this human CD62L(Low) T cell population provides initial insight regarding novel surface markers in TDLN T cells that might correlate with antitumor reactivity.