Macular Degeneration: Yasumura D

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A digest of articles written 1999 and later, on the topic "Macular Degeneration," originating from Planet Earth —» Yasumura D.  Display:  All Citations ·  All Abstracts
1 Article Retinal damage caused by photodynamic therapy can be reduced using BDNF. 2006

Duncan JL, Paskowitz DM, Nune GC, Yasumura D, Yang H, Matthes MT, Zarbin MA, LaVail MM. · University of California, San Francisco, California 94143, USA. · Adv Exp Med Biol. · Pubmed #17249587 No free full text.

This publication has no abstract.

2 Article BDNF reduces the retinal toxicity of verteporfin photodynamic therapy. free! 2004

Paskowitz DM, Nune G, Yasumura D, Yang H, Bhisitkul RB, Sharma S, Matthes MT, Zarbin MA, Lavail MM, Duncan JL. · Department of Ophthalmology, University of California, San Francisco, 94143-0730, USA. · Invest Ophthalmol Vis Sci. · Pubmed #15505074 links to  free full text

Abstract: PURPOSE: Verteporfin photodynamic therapy (PDT) is the most effective treatment for age-related macular degeneration, using laser activation of a photosensitizing dye to achieve closure of choroidal neovascularization. Although PDT preferentially affects pathologic vessels, it can also cause collateral damage to the overlying retina. In the current study, it was found that the neuroprotective agent brain-derived neurotrophic factor (BDNF) reduces this retinal damage. METHODS: Normal adult rats received intravitreal BDNF in one eye and PBS or no injection in the other eye 2 days before PDT. RESULTS: Control eyes exhibited choroidal hypofluorescence, moderate to severe photoreceptor loss, and depression of local retinal function measured using multifocal ERG in the laser-treated area. BDNF-injected eyes had more surviving photoreceptors and improved multifocal ERG responses 1 week after PDT. BDNF did not diminish the effect of PDT on the choroidal circulation as assessed by fluorescein angiography, and there was no evidence of retinal toxicity due to BDNF treatment. CONCLUSIONS: These results suggest that adjunctive neuroprotective therapy may reduce collateral damage to photoreceptors and improve visual outcome after PDT.