Isaacs Syndrome

Overview

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Is a:

Disease or Syndrome

Definition:

A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; fasciculation; hyporeflexia; muscle cramp; muscle weakness; hyperhidrosis; tachycardia; and myokymia. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from stiff-person syndrome). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann ny acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)

Synonyms:

Acquired Neuromyotonia
Continuous Muscle Activity Syndrome
Continuous Myokymia
Continuous Myokymias
Gamstorp Wohlfart Syndrome
Gamstorp-Wohlfart Syndrome
Gamstorp-Wohlfart Syndromes
Isaac Syndrome
Isaacs Mertens Syndrome
Isaacs Pseudomyotonia Syndrome
Isaacs' Syndrome
Isaacs-Mertens Syndrome
Myokymia, Continuous
Myokymias, Continuous
Neuromyotonia
Neuromyotonia, Acquired
Pseudomyotonia
Pseudomyotonia Syndrome of Isaacs
Quantal Squander
Syndrome of Continuous Muscle Activity
Syndromes, Gamstorp-Wohlfart
Syndromes, Isaacs-Mertens

Broader Topics:

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