Hypertension: Rebollo Alvarez P

Alvarez-Ude Cotera F, Rebollo Alvarez P. · Servicio de Nefrología, Hospital General Segovia. · Nefrologia. · Pubmed #19018740 No free full text.

Abstract: From the 1990s, various studies have provided data on health-related quality of life (HRQOL) in patients with chronic kidney disease (CKD) in stages previous to the initiation of kidney replacement therapy (KRT). The characteristics of these patients (Strength of Recommendation C) are: Patients with CKD have a deterioration in their HRQOL when compared with the general population. This deterioration is associated with various sociodemographic variables: age, gender, marital status, educational level and income. The deterioration is partly explained by the diseases that cause CKD (hypertension and diabetes), associated comorbid conditions (especially cardiovascular) and complications of CKD (anemia and malnutrition-inflammation). The progressive decline in glomerular filtration rate (GFR) is associated with a progressive deterioration of HRQOL, as well as an increase in the frequency and severity of certain symptoms and the impact (psychological distress) they cause. Physical dimensions are more affected than mental or social dimensions. Mental disturbances in patients with CKD can be summarized as follows: - There is an association between high levels of anxiety and low levels of sense of coherence with a reduction in wellbeing that in turn affects functional capacity for activities of daily living. - Psychological impairment from symptoms increases as GFR worsens. - This is a high level of correlation between perception of disease, depression and satisfaction with life. - Impairment of mental dimensions is greater in male, young, divorced, unemployed, smoker, and obese patients and in those who take more medication and have greater comorbidity. - Impairment of mental dimensions is negatively associated with albumin levels and hemoglobin. The recommended questionnaire for measurement of HRQOL in this type of patients is the SF-36. The SF-12 can be used as a shorter alternative and is suitable for evaluation of groups of patients.

Espuña Pons M, Puig Clota M, Pérez González A, Rebollo Alvarez P. · Institut Clínic de Ginecología, Obstetricia i Neonatología, Hospital Clínic, Universidad de Barcelona. · Actas Urol Esp. · Pubmed #15981426 links to  free full text

Abstract: BACKGROUND: There is little information about urodynamic characteristics of females with symptoms of urinary incontinence (UI) and nocturia. METHOD: Descriptive study of 1731 females consecutively referred with symptoms of UI for study and treatment. Urogynaecological history, physical examination and urodynamic study were carried out. Patients with pelvic organ prolapse greater than second degree were excluded. Frequency of nocturia symptom and its relationship with urodynamic, personal and clinical variables were analysed. RESULTS: 743 patients (43%) of those included presented nocturia. Urodynamic diagnoses in patients with nocturia were: stress UI in 262 patients (35.4%); detrusor overactivity in 166 (22.3%); and both in 220 (29.6%). The rest (12.7%) had other diagnoses. Mean (S.D.) bladder capacity of patients with nocturia was less than that of the rest of patients: 459.8 (159.8) vs 530.6 (216.9) ml (p<0.001). Of all the variables associated with nocturia, those which showed independent association were (ExpB; 95%CI): age >65 years (1.88; 1.34-2.63); menopause (2.11; 1.56-2.86); hypertension (1.42; 1.04-1.94) and bladder cistometric capacity less than 300 (1.71; 1.01-2.91) and between 300 and 400 (1.67; 1.17-2.38). The urodynamic diagnosis of Stress UI was associated with the absence of nocturia. CONCLUSION: Nocturia is a frequent symptom among females complaining of urinary incontinence. Its presence is associated to age over 65 years, menopause, hypertension and reduced bladder capacity.