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Review Cardiovascular consequences of cortisol excess. free! 2005
Whitworth JA, Williamson PM, Mangos G, Kelly JJ. · John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia. · Vasc Health Risk Manag. · Pubmed #17315601 links to free full text
Abstract: Cushing's syndrome is a consequence of primary or, more commonly, secondary oversecretion of cortisol. Cardiovascular disease is the major cause of morbidity and mortality in Cushing's syndrome, and excess risk remains even in effectively treated patients. The cardiovascular consequences of cortisol excess are protean and include, inter alia, elevation of blood pressure, truncal obesity, hyperinsulinemia, hyperglycemia, insulin resistance, and dyslipidemia. This review analyses the relationship of cortisol excess, both locally and at tissue level, to these cardiovascular risk factors, and to putative mechanisms for hypertension. Previous studies have examined correlations between cortisol, blood pressure, and other parameters in the general population and in Cushing's syndrome. This review also details changes induced by short-term cortisol administration in normotensive healthy men.
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