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Editorial Higher total cholesterol, cognitive decline, and dementia. 2009
Panza F, Solfrizzi V, D'Introno A, Colacicco AM, Santamato A, Seripa D, Pilotto A, Capurso A, Capurso C. · Department of Geriatrics, Center for Lipoprotein Metabolism, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy. · Neurobiol Aging. · Pubmed #18179846 No free full text.
This publication has no abstract.
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Article ApoE gene delivery inhibits severe hypercholesterolemia in newborn ApoE-KO mice. 2007
Signori E, Rinaldi M, Fioretti D, Iurescia S, Seripa D, Perrone G, Norata GD, Catapano AL, Fazio VM. · Institute of Neurobiology and Molecular Medicine, CNR-ARTOV, 00133 Rome, Italy. · Biochem Biophys Res Commun. · Pubmed #17662693 No free full text.
Abstract: Apolipoprotein E, a key regulator in cholesterol-rich lipoprotein metabolism, is considered a strong candidate for treating hypercholesterolemia and cardiovascular disease. Inherited deficiency of this protein results in type III hyperlipoproteinemia in humans. ApoE-knockout mice, which develop spontaneous hypercholesterolemia, are an excellent model of human atherosclerosis. Here we investigated the therapeutic effects of a plasmid vector encoding human APOE3 sequence intramuscularly injected in hypercholesterolemic newborn mice at the ages of 5 and 14 days. We further explored the possibility of inducing tolerance in newborns when injected early. Our data show that direct i.m. naked DNA injection reduces severe hypercholesterolemia in newborn mice. Moreover, when naked DNA is administrated early, no immune response is generated against the human APOE, allowing repeated administrations. Neonatal therapies are important for the treatment of many genetic childhood diseases where early administration is required to prevent developmental damage. We propose the use of direct i.m. naked gene transfer in newborns to prevent long-term damages arising from hypercholesterolemic conditions.
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Article Absence of apolipoprotein B3500 mutation in type 2a hyperlipoproteinemia patients and in the general population from southern Italy. 1999
Seripa D, Gravina C, Volpe R, Margaglione M, Papa S, Merla G, Parrella P, Di Minno G, Ricci G, Testa M, Fazio VM. · Laboratorio Patologia Molecolare e Terapia Genica, IRCCS H. Casa Sollievo Sofferenza, San Giovanni Rotondo, FG, Italy. · J Inherit Metab Dis. · Pubmed #10399102 No free full text.
This publication has no abstract.
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