Hyperlipidemias: Murphy MH

Murphy MH, Blair SN, Murtagh EM. · Sport and Exercise Sciences Research Institute, University of Ulster, Newtownabbey, County Antrim, Northern Ireland. · Sports Med. · Pubmed #19093694 No free full text.

Abstract: Current physical activity guidelines endorse the notion that the recommended amount of daily physical activity can be accumulated in short bouts performed over the course of a day. Although intuitively appealing, the evidence for the efficacy of accumulated exercise is not plentiful. The purpose of this review was to compare the effects of similar amounts of exercise performed in either one continuous or two or more accumulated bouts on a range of health outcomes. Sixteen studies met the selection criteria for inclusion in the review, in which at least one outcome known to affect health was measured before and after continuous and accumulated exercise training interventions. Where improvements in cardiovascular fitness were noted, most studies reported no difference in the alterations between accumulated and continuous patterns of exercise. In the few studies where a normalization of blood pressure was observed from baseline to post-intervention, there appear to be no differences between accumulated and continuous exercise in the magnitude of this effect. For other health outcomes such as adiposity, blood lipids and psychological well-being, there is insufficient evidence to determine whether accumulated exercise is as effective as the more traditional continuous approach. Seven short-term studies in which at least one health-related outcome was measured during the 0- to 48-hour period after a single continuous bout of exercise and a number of short bouts of equivalent total duration were included in the review. Many of the studies of such short-term effects considered the plasma triglyceride response to a meal following either accumulated short or continuous bouts of exercise. Collectively, these studies suggest that accumulated exercise may be as effective at reducing postprandial lipaemia. Further research is required to determine if even shorter bouts of accumulated exercise (<10 minutes) confer a health benefit and whether an accumulated approach to physical activity increases adherence among the sedentary population at whom this pattern of exercise is targeted.

Mc Clean CM, Mc Laughlin J, Burke G, Murphy MH, Trinick T, Duly E, Davison GW. · Sport and Exercise Sciences Research Institute, School of Sports Studies, University of Ulster, Shore Road, Newtownabbey, County Antrim, BT37 OQB, UK. · Eur J Appl Physiol. · Pubmed #17323071 No free full text.

Abstract: Oxidative stress is postulated to be responsible for the postprandial impairments in vascular function. The purpose of this study was to measure pulse wave velocity (PWV) and markers of postprandial oxidative stress before and after an acute bout of moderate exercise. Ten trained male subjects (age 21.5 +/- 2.5 years, VO2 max 58.5 +/- 7.1 ml kg(-1) min(-1)) participated in a randomised crossover design: (1) high-fat meal alone (2) high-fat meal followed 2 h later by a bout of 1 h moderate (60% max HR) exercise. PWV was examined at baseline, 1, 2, 3, and 4 h postprandially. Blood Lipid hydroperoxides (LOOHs), Superoxide dismutase (SOD) and other biochemical markers were measured. PWV increased at 1 h (6.49 +/- 2.1 m s(-1)), 2 h (6.94 +/- 2.4 m s(-1)), 3 h (7.25 +/- 2.1 m s(-1)) and 4 h (7.41 +/- 2.5 m s(-1)) respectively, in the control trial (P < 0.05). There was no change in PWV at 3 h (5.36 +/- 1.1 m s(-1)) or 4 h (5.95 +/- 2.3 m s(-1)) post ingestion in the exercise trial (P > 0.05). LOOH levels decreased at 3 h post ingestion in the exercise trial compared to levels at 3 h (P < 0.05) in the control trial. SOD levels were lower at 3 h post ingestion in the control trial compared to 3 h in the exercise trial (0.52 +/- 0.05 vs. 0.41 +/- 0.1 units mul(-1); P < 0.05). These findings suggest that a single session of aerobic exercise can ameliorate the postprandial impairments in arterial function by possibly reducing oxidative stress levels.