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Article Relationship of office, home, and ambulatory blood pressure to blood glucose and lipid variables in the PAMELA population. free! 2005
Mancia G, Facchetti R, Bombelli M, Polo Friz H, Grassi G, Giannattasio C, Sega R. · Istituto di Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università Milano-Bicocca, Ospedale S Gerardo, Monza, Milan, Italy. · Hypertension. · Pubmed #15867138 links to free full text
Abstract: Alterations in blood glucose and cholesterol are more frequently detectable in hypertensive than in normotensive conditions. However, no information exists as to whether this phenomenon involves only office or also home and 24-hour ambulatory blood pressure (ie, when values are representative of daily life). In 2045 subjects enrolled in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study, we measured home, 24-hour, and office blood pressure. Measurements also included fasting blood glucose and serum total and HDL cholesterol values. Prevalence of diabetes (> or =126 mg/dL or use of antidiabetic drugs), impaired fasting blood glucose (> or =110 to <126 mg/dL), and hypercholesterolemia (serum total cholesterol > or =240 mg/dL or 200 mg/dL) increased progressively from "optimal" to "normal," "high-normal," and "elevated" office systolic or diastolic blood pressure. Fasting blood glucose and total serum cholesterol also increased progressively from the first to the fourth group, with HDL cholesterol values showing a concomitant progressive decrease. This was also the case for quartiles of office, home, and 24-hour blood pressure. In the whole population, there was a positive correlation between serum cholesterol or blood glucose and all blood pressure values (P always <0.0001), with a much smaller and less consistent relationship with heart rate. In a multivariate analysis that included gender, body mass index, age, and antihypertensive treatment, all blood pressure values remained highly significantly related to values of either metabolic variables. Thus, in the PAMELA population, glucose and lipid values are independently related to blood pressure. This is also the case when daily life blood pressure values are considered.
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Article [The cardiovascular risk score and its application in the DAI study] free! 2003
Grassi G, Monge L. · Unità Operativa Malattie Metaboliche e Diabetologia, Azienda Ospedaliera San Giovanni Battista, Corso Bramante 88, 10126 Torino. · Ann Ist Super Sanita. · Pubmed #14587211 links to free full text
Abstract: Aim of this study was to estimate the risk of coronary heart disease (CHD) in a cohort of type 2 diabetics included in the DAI study. We analysed 8200 patients, 40-74 years of age, with no history of cardiovascular complications. The formulae derived from the Framingham Heart Study were used. More than 60% of the cohort have a high risk of CHD. Among the under-50s, only 10% have a high risk in the short-term but, according to the predictions at age 60, 76.8% are at high risk. In the age class 50-60 years 1 in 3 women and 2 in 3 men are at high risk. In conclusion, our group of type 2 diabetics are at high risk of CHD both in the short and in the long term.
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