| Review [Transplant coronary artery disease--treatment with statins] 2004
Wolszakiewicz J, Bilińska M. · Klinika i Zakład Rehabilitacji Kardiologicznej i Elektrokardiologii Nieinwazyjnej Instytutu Kardiologii w Warszawie. · Pol Merkur Lekarski. · Pubmed #15518430 No free full text.
Abstract: Hypercholesterolemia is a common disorder after heart transplantation and my be associated with the development of transplant coronary artery disease. 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibitors (HMG CoA) are the most effective drugs to lower cholesterol level in transplant patients. However, interaction of immunosuppressants with HMG CoA inhibitors, which are metabolized by cytochrome P 450, increase incidence of skeletal muscle myopathy and rhabdomyolysis.
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