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Review [Recurrent acute liver toxicity from intravenous methylprednisolone] free! 2008
Rivero Fernández M, Riesco JM, Moreira VF, Moreno A, López San Román A, Arranz G, Ruiz Del Arbol L. · Servicios de Gastroenterología, Hospital Ramón y Cajal. Madrid. Spain. · Rev Esp Enferm Dig. · Pubmed #19159178 links to free full text
Abstract: Adverse drug reactions (hepatotoxicity) are a frequent cause of acute liver injury with a wide clinical and histological spectrum. An early recognition of drug-related liver disease has been considered essential in clinical practice due to potential risks. In most cases exposure discontinuation improves the clinical picture.Steroids are used in a variety of clinical settings. However, intravenous steroids have rarely been associated with hepatotoxicity. We report the case of a middle-aged woman with multiple sclerosis who received a bolus of methylprednisolone on three occasions for the management of relapsing disease, with the development of repeated episodes of elevated liver enzymes after corticoid administration. In the third episode a liver biopsy was performed, which showed acute hepatitis with bridging necrosis; such histological picture has not been described before in patients treated with intravenous steroids.
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Article [Constitutional syndrome associated to metformin induced hepatotoxicity] 2008
de la Poza Gómez G, Rivero Fernández M, Vázquez Romero M, Angueira Lapeña T, Arranz de la Mata G, Boixeda de Miquel D. · Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid, Spain. · Gastroenterol Hepatol. · Pubmed #19174081 No free full text.
Abstract: Metformin is an oral antidiabetic agent frequently used to manage type II diabetes. This drug produces nonspecific gastrointestinal symptoms in 5-20% of patients and, more rarely, has also been associated with severe adverse effects such as lactic acidosis. Only a few isolated cases of hepatotoxicity due to this drug have been documented. We report the case of an 83-year-old man with constitutional syndrome and hepatic biochemical alterations, which were attributed to metformin after ruling out an oncologic etiology and observing complete clinical and biochemical resolution after withdrawal of the drug.
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Article [Patient's information. Hepatitis E] 2008
Crespo Pérez L, Rivero Fernández M. · Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid. · Rev Esp Enferm Dig. · Pubmed #18953767 No free full text.
This publication has no abstract.
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