Hepatitis: Ramanarayanan J

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A digest of articles written 1999 and later, on the topic "Hepatitis," originating from Planet Earth —» Ramanarayanan J.  Display:  All Citations ·  All Abstracts
1 Review Review: hepatotoxicity and EGFR inhibition. 2008

Ramanarayanan J, Krishnan GS. · Stratton VA Medical Center, Albany, NY 12208, USA. · Clin Adv Hematol Oncol. · Pubmed #18391919 No free full text.

This publication has no abstract.

2 Article Acute drug induced hepatitis due to erlotinib. free! 2007

Ramanarayanan J, Scarpace SL. · Division of Hematology and Oncology, Stratton VA Medical Center, Albany, NY 12208, USA. · JOP. · Pubmed #17228132 links to  free full text

Abstract: CONTEXT: Acute drug induced hepatitis has not been commonly associated with epidermal growth factor receptor (EGFR) inhibitors. Hepatotoxicity seen with erlotinib, a small molecule tyrosine kinase inhibitor to EGFR, is usually transient with mild elevation of transaminases. CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer. Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values. CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib. As EGFR inhibitors are now incorporated with chemotherapy in advanced pancreatic cancers, clinicians should be aware of this potential complication.