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Review Mitral valve vegetation and cerebral emboli in a primary antiphospholipid syndrome patient who had hepatitis C virus infection: report of a case and review of the literature. 2003
Pamuk ON, Cakir N, Soy M, Aktoz M, Celik Y, Akdemir O. · Koca Sinan Mah, Sadik Ahmet Cad Varli Apt No: 25 Daire:2, Edirne, Turkey. · Clin Rheumatol. · Pubmed #12740679 No free full text.
Abstract: We report the case of 36-year-old woman who came to us with a history of recurrent miscarriages and who was later diagnosed as having primary antiphospholipid syndrome (PAPS) and chronic hepatitis C virus (HCV) infection. The patient was referred to us with generalised seizures; cranial MRI revealed multiple embolic infarcts in both frontal lobes and a focal cortical infarct in the left frontoparietal lobe. Her echocardiography showed mitral valve vegetation and insufficiency. The patient was put on oral anticoagulant therapy and during her 8-month follow-up period no thrombotic events occurred. We report this case because it was the first in which PAPS, valvular disease, a cerebral embolic event and HCV infection were coexistent in the same patient. We also review other cases in which there was valvular vegetation and a cerebral ischaemic event associated with PAPS.
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Article Successful treatment with adefovir of one patient whose cryoglobulinemic vasculitis relapsed under lamivudine therapy and who was diagnosed to have HBV virologic breakthrough with YMDD mutations. free! 2006
Cakir N, Pamuk ON, Umit H, Midilli K. · Department of Rheumatology, Trakya University Medical Faculty, Edirne-TURKEY. · Intern Med. · Pubmed #17139120 links to free full text
Abstract: We report a patient whose cryoglobulinemic vasculitis recurred due to reactivation of lamivudine-resistant HBV. Our patient with hepatitis B-related cryoglobulinemic vasculitis was administered lamivudine. Her vasculitis regressed, ALT normalized, HBV-DNA became negative. Under lamivudine therapy, her cryoglobulinemic cutaneous vasculitis recurred. ALT increased significantly; it was found that tyrosine-methionine-aspartate-aspartate (YMDD) motif in the DNA polymerase gene had been replaced by YIDD. Adefovir was added to lamivudine. During follow-up, her purpura disappeared, ALT normalized, HBV-DNA became negative. Our patient is the first whose cryoglobulinemic vasculitis recurred under lamivudine, who had a HBV virologic breakthrough with YMDD mutation, and was successfully treated with adefovir.
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Article Prevalence of serum antibodies to hepatitis B and C viruses in patients with primary glomerulonephritis. 2001
Altiparmak MR, Pamuk ON, Pamuk GE, Mert A, Ataman R, Serdengeçti K. · Department of Nephrology, Cerrahpaşa Medical Faculty, University of Istanbul, Turkey. · J Nephrol. · Pubmed #11730272 No free full text.
Abstract: We retrospectively analysed the medical records of patients who underwent renal biopsy in our nephrology department over the past 8 years. Our aim was to discover the frequency of hepatitis B (HBV) and hepatitis C virus (HCV) in patients with primary glomerulonephritis (GN) in Turkey, a moderately endemic country for both infections. The study included 144 male and 104 female patients aged between 12-70 years. The frequency of HBsAg and anti-HCV were found to be similar to healthy controls, respectively 6.5% and 1.6% (p>0.05). As is true for low endemic countries, HBV and HCV infections might be rarely associated with GN in Turkey.
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Minor A case of PAN complicated by nephrotic syndrome after acute hepatitis B. 2001
Pamuk GE, Pamuk ON, Altiparmak MR, Sentürk H, Parman Y, Minareci O, Ozbay G. · No affiliation provided · Clin Rheumatol. · Pubmed #11642525 No free full text.
This publication has no abstract.
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