Hepatitis: Ozturk R

Mert A, Tabak F, Ozaras R, Ozturk R, Aki H, Aktuglu Y. · Cerrahpasa Medical Faculty, Infectious Diseases and Clinical Microbiology, University of Istanbul, 34303 Aksaray, Istanbul, Turkey. · Intern Med. · Pubmed #15206561 links to  free full text

Abstract: During the course of typhoid fever, the usual histologic finding of the liver is "nonspecific reactive hepatitis." Hepatic granuloma (HG) is a rare complication of typhoid fever. We present two cases of typhoid fever with HG and review the relevant literature. Case 1 (a 53-year-old female) was found to have both hepatic and splenic granulomas. This is the first case of typhoid fever with splenic granulomas in the English language literature. Case 2 (a 66-year-old male) developed granulomas in the bone marrow in addition to HG. It should be considered that typhoid fever may lead to granulomas in several organs.

Tabak F, Mert A, Ozaras R, Biyikli M, Ozturk R, Ozbay G, Senturk H, Aktuglu Y. · Department of Clinical Bacteriology and Infectious Diseases, Cerrahpasa Medical Faculty, Istanbul University, Beylerbeyi 81210 Istanbul, Turkey. · J Clin Gastroenterol. · Pubmed #11960076 No free full text.

Abstract: Losartan, an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. Clinical experience with this drug has demonstrated that it is safe. Losartan-induced hepatic toxicity is extremely rare. We report a case of severe hepatic toxicity and fibrosis caused by losartan use, and we review four previously reported cases. Drug-induced hepatic injury may be seen during the treatment of hypertension by losartan and the clinician should be aware of this toxicity, especially during the initial phase of treatment.

Ulualp KM, Hamzaoglu I, Ulgen SK, Sahin DA, Saribas S, Ozturk R, Cebeci H. · Istanbul University Cerrahpasa Medical School, Turkey. · Surg Laparosc Endosc Percutan Tech. · Pubmed #10789574 No free full text.

Abstract: Nosocomial infections associated with interventional procedures have been attributed to improper decontamination of instruments. Disinfection of solid laparoscopic instruments, such as telescopes, by 2% glutaraldehyde and ethylene oxide was shown to be effective in preventing infection transmission. However, instrument design in more complex surgical instruments may hamper the quality of disinfection. The aim of this study is to investigate the safety of hospital disinfection of disposable laparoscopic instruments with a relatively more complex design. A total of 40 laparoscopic trocars were divided into two equal groups: group 1 was contaminated with bacteria and yeast, and group 2 was contaminated with the hepatitis B virus. Each group was then divided to two equal subgroups. After disinfecting subgroup A with 2% glutaraldehyde and B with ethylene oxide, samples were obtained for bacterial cultures and for virus detection using polymerase chain reaction (PCR). Bacterial and yeast cultures were positive in three instruments in group 1A and in two instruments in group 1B. Tests results for the hepatitis B virus were negative in group 2A, but positive in group 2B. Results of this study indicate that disinfection for multiple use of disposable laparoscopic instruments with a relatively complex structure is not effective and may result in nosocomial disease transmission by bacteria, fungi, and viruses.

Ozaras R, Tabak F, Tahan V, Ozturk R, Akin H, Mert A, Senturk H. · Department of Infectious Diseases, Cerrahpasa Medical Faculty, Istanbul University, 34098, Cerrahpasa, Istanbul, Turkey. · Dig Dis Sci. · Pubmed #18409002 No free full text.

Abstract: BACKGROUND AND AIM: Viral load is used for the diagnosis and monitoring the treatment of chronic hepatitis B (CHB). These methods are molecular-based and are expensive. Previous studies suggest that quantitative hepatitis B surface antigen (HBsAg) studied by automated chemiluminescent microparticle immunoassay can be a surrogate marker. In this study, we aimed to investigate whether quantitative HBsAg correlates hepatitis B virus (HBV) DNA levels during CHB treatment. METHODS: The study included 18 patients (13 male, 5 female, mean age: 33 +/- 9 years) with CHB. They were given pegylated interferon +/- lamivudine for 52 months and serum samples were obtained in weeks 0, 4, 8, 24, 48, 52, and 76. HBV DNA was measured by TaqMan polymerase chain reaction (PCR; Erasmus MC, University Medical Center, Rotterdam, The Netherlands). Quantitative HBsAg was studied by automated chemiluminescent microparticle immunoassay (Architect HBsAg, Abbott, IL). Results HBV DNA levels were measured as follows: 9.66, 7.69, 7.06, 5.93, 5.89, 5.88, and 7.27 logarithmic genome equivalent/ml, respectively. The corresponding HBsAg quantitation results were 42,888, 31,176, 37,882, 27,277, 28,279, 29,471, and 31,535 IU/ml, respectively. They showed a significant correlation (canonical correlation = 0.85). CONCLUSIONS: HBsAg studied by automated chemiluminescent microparticle immunoassay correlates with HBV DNA and can be a surrogate marker during the monitoring of the efficacy of HBV treatment.

Aras C, Ozdamar A, Ergin S, Ozturk R, Midilli K, Karacorlu M, Ozkan S. · Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. · Ophthalmologica. · Pubmed #15802933 No free full text.

Abstract: PURPOSE: To assay the vitreous of asymptomatic hepatitis B virus (HBV) carriers for the presence of HBV DNA using polymerase chain reaction (PCR). METHODS: Vitreous and serum specimens were collected from 13 carriers of HBV. The presence of HBV DNA was investigated by using PCR and Digene's Hybrid Capture System. The presence of hepatitis B surface antigen (HBsAg) in vitreous was also investigated by using the enzyme immunoassay (EIA). RESULTS: The serum was positive for HBV DNA in3 of the 13 asymptomatic carriers using PCR. Vitreous samples of all the patients, including 3 patients who were positive for HBV DNA in serum, were negative for HBV DNA with PCR and were negative for HBsAg with EIA. CONCLUSION: There is no evidence of HBV in the vitreous of asymptomatic HBV carriers.

Ozaras R, Mert A, Yilmaz MH, Celik AD, Tabak F, Bilir M, Ozturk R. · Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Medical Faculty, 34303 Cerrahpasa, Istanbul, Turkey. · J Clin Gastroenterol. · Pubmed #12811216 No free full text.

Abstract: Acute hepatitis A virus (HAV) infection is frequent in developing countries. Although some gallbladder abnormalities are defined during the course, an acute cholecystitis is extremely rare. We here report 2 additional cases of cholecystitis due to acute HAV infection and review the previously reported 2 cases. One of our patients was admitted with jaundice and a suspicious portal mass with a presumed diagnosis of cholagiocarcinoma. The other presented with jaundice, abdominal pain, and constitutional symptoms. Both patients were planned to be operated on. During the follow-up, absence of fever, leukocytosis, acute-phase protein response, and calculus in biliary system were against the diagnosis of a bacterial cholecystitis. Moreover the course of cholecystitis was closely parallel to that of the HAV infection. Both patients were managed conservatively. It was concluded that rare, acute viral cholecystitis can develop during the course of acute HAV infection.

Ozaras R, Ipekci S, Kumbasar H, Aybar Y, Tahan V, Mert A, Ozturk R, Tabak F. · No affiliation provided · J Clin Gastroenterol. · Pubmed #18607296 No free full text.

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Ozaras R, Celik AD, Kisacik B, Mert A, Aki H, Ozturk R, Tabak F. · No affiliation provided · J Clin Gastroenterol. · Pubmed #12811220 No free full text.

This publication has no abstract.

Tahan V, Ozaras R, Uzunismail H, Mert A, Tabak F, Ozturk R, Aktuglu Y, Ozbay G. · No affiliation provided · J Clin Gastroenterol. · Pubmed #11418805 No free full text.

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Mert A, Tabak F, Ozturk R, Aktuglu Y, Ozaras R, Kanat M. · No affiliation provided · J Clin Gastroenterol. · Pubmed #11319332 No free full text.

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Mert A, Altintas A, Ozaras R, Bilir M, Tabak F, Ozturk R, Siva A, Aktuglu Y, Senturk H. · No affiliation provided · Mult Scler. · Pubmed #11185061 No free full text.

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Tabak F, Mert A, Ozturk R, Ergin S, Senturk H, Aktuğlu Y. · No affiliation provided · Scand J Infect Dis. · Pubmed #10959666 No free full text.

This publication has no abstract.