Hepatitis: Nishise Y

Saito T, Nishise Y, Ishii R, Watanabe H, Suzuki K, Kawata S. · Department of Gastroenterology, Yamagata University School of Medicine, Japan. · Nippon Shokakibyo Gakkai Zasshi. · Pubmed #19346718 No free full text.

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Saito T, Nishise Y, Makino N, Haga H, Ishii R, Okumoto K, Ito JI, Watanabe H, Saito K, Takeda H, Togashi H, Kubota I, Daimon M, Kato T, Kawata S. · Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990-9585, Japan. · Metabolism. · Pubmed #19411086 No free full text.

Abstract: Measurement of the serum alanine aminotransferase (ALT) level is used as an initial test for detection of liver diseases, and recent studies have also highlighted its potential value as a measure of overall health and survival as a marker of an increased risk of metabolic disorder. This study was designed to clarify the prevalence of elevated ALT levels in the Japanese population and to assess factors associated with ALT elevation. The subjects were 2165 individuals aged 40 to 85 years who participated in a Japanese community-based study referred to as the Takahata Study. Serum ALT levels and factors associated with ALT elevation were investigated. Among 2087 subjects who were negative for hepatitis B and C, the rates of elevated ALT greater than 30 U/L in men and greater than 25 U/L in women were 217 (22.7%) of 957 and 239 (21.2%) of 1130, respectively. These ALT cutoff levels had a specificity of more than 80% for exclusion of subjects with none or 1 of 3 metabolic risk factors: hypertension, lipid metabolism abnormality, and hyperglycemia. Multivariate analysis revealed 5 factors with a significant association with ALT elevation in men (n = 957): high gamma-glutamyltranspeptidase, low adiponectin, high low-density lipoprotein cholesterol, high body mass index, and high homeostasis model assessment insulin resistance index. Similarly, 4 factors were significantly associated with ALT elevation in women (n = 1130): high gamma-glutamyltranspeptidase, low adiponectin, high body mass index, and high homeostasis model assessment insulin resistance index. These results suggest that elevated ALT levels in the Japanese population older than 40 years have a strong association with metabolic syndrome-related features including obesity and insulin resistance.

Karasawa T, Togashi H, Tajima K, Suzuki A, Onodera S, Haga H, Ishii R, Misawa K, Sanjo M, Okumoto K, Nishise Y, Ito J, Sugahara K, Saito K, Saito T, Kawata S. · Department of Gastroenterology, Yamagata University Faculty of Medicine, Japan. · Nippon Shokakibyo Gakkai Zasshi. · Pubmed #19262055 No free full text.

Abstract: We report a case of chronic hepatitis C complicated with idiopathic thrombocytopenic purpura (ITP), successfully treated with interferon (IFN) beta. A 65-year-old woman was admitted to our hospital for the treatment of chronic hepatitis C with IFN beta. ITP was also diagnosed because of the presence of platelet associated IgG and the findings of bone marrow examination. We started IFN therapy, which resulted in normalization of transaminases, complete HCV eradication, and increased number of platelet.

Sugahara K, Saito T, Watanabe H, Misawa K, Ishii R, Suzuki A, Haga H, Sanjo M, Okumoto K, Nishise Y, Ito J, Saito K, Togashi H, Kawata S. · Department of Gastroenterology, Yamagata University School of Medicine. · Nippon Shokakibyo Gakkai Zasshi. · Pubmed #17917401 No free full text.

Abstract: This report describes our experience with two cases of pyogenic spondylitis with chronic hepatitis C during combination therapy of interferon alfa and ribavirin. The first patient, a 59-year-old man, was treated conservatively and improved, but the second patient, a 69-year-old woman, was not improved by conservative therapy and reconstructive operation was performed. The combination therapy of interferon alfa and ribavirin has a high risk of severe infectious diseases as side effects. CT scan and MRI are recommended immediately to diagnose pyogenic spondylitis, when patients has pyrexia and lumbago with laboratory data suspected inflammation during interferon therapy.

Nishise Y, Saito T, Sugahara K, Ito JI, Saito K, Togashi H, Nagano-Fujii M, Hotta H, Kawata S. · Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan. · J Infect Dis. · Pubmed #17763321 No free full text.

Abstract: We conducted a retrospective study of 65 patients with chronic hepatitis C, to determine whether the secondary structure of the amino-terminal 120 residues of the hepatitis C virus (HCV) NS3 protein is associated with an increased risk of development of hepatocellular carcinoma (HCC). The cumulative incidence of HCC was highest among patients infected with group B HCV-1b, wherein the risk of HCC significantly increased compared with that among patients infected with group A (hazard ratio, 4.95 [95% CI, 1.43-17.11]) after adjustment for age and histological stage. This HCV-1b grouping may be a useful marker for detecting the risk of development of HCC.

Nishise Y, Fukao A, Takahashi T. · Division of Public Health and Preventive Medicine, Department of Diagnostic Information and Socioenvironmental Medicine, Yamagata University School of Medicine, Iida-nishi, Japan. · J Epidemiol. · Pubmed #14604222 No free full text.

Abstract: BACKGROUND: Helicobacter pylori infection is related to several gastroduodenal diseases, though the route of transmission remains unclear. METHODS: A cross-sectional study that included 695 healthy people (males 308, females 387; median age 60 years) participating in a health checkup program in Yamagata Prefecture was conducted. H. pylori status was determined in all subjects by evaluation of serum anti-H. pylori immunoglobulin G antibody. Antibody against hepatitis A virus was used as a marker of fecal-oral exposure to assess the agreement between H. pylori infection and hepatitis A virus infection. Data on other factors known or suspected to be related to infection status were also collected using a questionnaire. RESULTS: Seroprevalence of H. pylori and hepatitis A virus was 60% and 70%, respectively. Kappa values for subjects aged 20-49 and aged 50 or older were 0.07 and 0.02, respectively, and agreement between the presences of both infections was assessed as slight. In the multivariate logistic regression analysis, H. pylori infection was significantly associated with availability of a sewage system in childhood (presence [reference], absence [odds ratio (OR) = 4.06, 95% confidence interval (CI): 1.36-13.94]) and the number of gastrointestinal endoscopies undergone (none [reference], once [OR = 1.64, 95% CI: 0.83-3.27], 2-3 times [OR = 3.11, 95% CI: 1.65-5.99], or 4 or more times [OR = 3.18, 95% CI: 1.71-6.03]), (p < 0.01 for trend). CONCLUSIONS: Our results suggest that poor hygiene in childhood is related to H. pylori infection. The fecal-oral route does not seem to be an important mode of transmission, but the possibility of transmission by gastrointestinal endoscopic examination exists.