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Review [Case of extra-hepatic lymph node metastasis of hepatocellular carcinoma with no evident sign of intra-hepatic recurrence] 2009
Morita S, Matsuda Y, Oshima T, Kubota T, Kawauchi Y, Kobayashi M, Nomoto M, Aoyagi Y. · The Third Department of Internal Medicine, Niigata University School of Medicine, Japan. · Nippon Shokakibyo Gakkai Zasshi. · Pubmed #19262054 No free full text.
Abstract: A 73-year-old man with chronic hepatitis C was Successfully treated for hepatocellular carcinoma (HCC) by localized treatment. During the follow-up period, abdominal computed tomography (CT) revealed no HCC recurrence in the liver. However, 9 months after the treatment, abdominal lymph nodes appeared enlarged on CT. Laparoscopic biopsy of the lymph nodes showed that the lesion was HCC, and TS-1/cisplatin chemotherapy was performed. However, extra-hepatic lymph nodes rapidly grew, leading to obstructive jaundice and finally death 10 months after of HCC metastasis. Although abdominal lymph node metastasis of HCC has been widely considered to be rare, the confirmation of effective therapy is awaited because histological studies have suggested that this pathologic lesion may occur more often than expected.
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Article [A case of drug-induced liver injury caused by entecavir for treatment of hepatitis B virus reactivation during RCHOP in a patient with non-Hodgkin lymphoma] 2009
Kondo M, Kitada N, Kobayashi M, Morita S, Yoshioka M, Tsuji T, Mori A, Okamoto T, Watari M. · Dept. of Pharmacy, Takarazuka Municipal Hospital. · Gan To Kagaku Ryoho. · Pubmed #19620818 No free full text.
Abstract: A 49-year-old-man, a healthy carrier of hepatitis B virus (HBV), received chemotherapy with a rituximab/cyclo- phosphamide/doxorubicin/vincristine/prednisolone (R-CHOP) regimen for non-Hodgkin's lymphoma. At the first course of chemotherapy, not only the liver function but the HBV DNA level was elevated. These symptoms were diagnosed as hepatic injury induced by HBV reactivation, and, therefore, entecavir (ETV) was started. As a result, although the treatment with ETV decreased the HBV DNA level, liver function values were remarkably elevated again (over 3 times the levels before beginning ETV). ETV was discontinued because of suspicion regarding the onset of hepatic injury it caused. After switching to lamivudine (LVD), the liver function quickly improved and no problems were observed with renewal of the R-CHOP regimen. In addition, the HBV DNA level decreased and 3 courses of R-CHOP were performed successfully. In our case, the hepatic injury was induced by ETV, although anti-HBV medicine was used for the treatment of HBV reactivation according to the guideline. Therefore, the medical staff must carefully and consistently observe patients with HBV infection after chemotherapy.
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Minor Autoimmune hepatitis accompanied by idiopathic thrombocytopenic purpura and Sjögren's syndrome. free! 2002
Yamaike N, Saigo K, Imoto S, Miyachi H, Morita S, Maeda Y, Tomofuji Y, Chinzei T. · No affiliation provided · Intern Med. · Pubmed #11838605 links to free full text
This publication has no abstract.
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