Hepatitis: Levesque H

Belizna CC, Hamidou MA, Levesque H, Guillevin L, Shoenfeld Y. · Internal Medicine Department, CHU Rouen, Rouen, France. · Rheumatology (Oxford). · Pubmed #19258377 No free full text.

Abstract: Vasculitis may be associated with infection, immunization or anti-microbial drugs. Infections are responsible for a number of different types of vasculitis. Conversely, patients with vasculitis may develop infections, which sometimes mimic relapse. The aim of this review is to summarize the various aspects of the inter-relationship between vasculitis and infection, and the physiopathological mechanisms involved, in light of our current knowledge from animal models. Currently, a causal relationship between infection and vasculitis has only been established in a few instances and many mechanisms remain hypothetical. This inter-relationship is further assessed from the point of view of clinical presentation and therapeutic options, based on case reports and prospective observational data.

Marie I, Levesque H, Tranvouez JL, François A, Riachi G, Cailleux N, Courtois H. · Department of Internal Medicine, Centre Hospitalier Universitaire de Rouen-Boisguillaume, 76031 Rouen Cedex, France. · Rheumatology (Oxford). · Pubmed #11157149 links to  free full text

Abstract: OBJECTIVE: We report the cases of two patients with the complete CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) of systemic sclerosis (SSc) who developed autoimmune hepatitis. RESULTS: Our findings suggest that autoimmune hepatitis can be considered to be one of the liver manifestations associated with SSc. Our data also indicate that, because liver involvement may precede skin manifestations, evaluation for SSc is appropriate when autoimmune hepatitis is noted, and that the evaluation should include clinical examination, testing for antinuclear antibodies (especially for anticentromere antibodies) and nailfold capillaroscopy. CONCLUSIONS: From a practical point of view, our two cases emphasize that suspicion of autoimmune hepatitis in SSc patients presenting with cytolytic hepatitis will help to achieve both accurate diagnosis and optimal management.

Hervé F, Bernet J, Robaday S, François A, Levesque H, Marie I. · No affiliation provided · Rev Med Interne. · Pubmed #16129519 No free full text.

This publication has no abstract.

Marie I, Levesque H, Courtois H, François A, Riachi G. · No affiliation provided · Ann Rheum Dis. · Pubmed #11203156 links to  free full text

This publication has no abstract.