Hepatitis: Brook MG

Gilson R, Brook MG. · Centre for Sexual Health And HIV Research, Royal Free and University College Medical School, The Mortimer Market Centre, London WC1E 6AU, UK. · Sex Transm Infect. · Pubmed #17151052 No free full text.

This publication has no abstract.

Nelson M, Matthews G, Brook MG, Main J, Anonymous00327, Anonymous00328. · Patrick Clements Clinic, Central Middlesex Hospital, London, UK. · HIV Med. · Pubmed #16011539 No free full text.

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Brook MG, Gilson R, Wilkins E, Anonymous00325, Anonymous00326. · Central Middlesex Hospital, London, UK. · HIV Med. · Pubmed #16011538 No free full text.

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Nelson MR, Matthews G, Brook MG, Main J, Anonymous00076. · Chelsea and Westminster Hospital, London, UK. · HIV Med. · Pubmed #14511248 No free full text.

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Brook MG, Gilson R, Wilkins EL, Anonymous00075. · Central Middlesex Hospital, London, UK. · HIV Med. · Pubmed #14511247 No free full text.

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Brook MG, Anonymous00156. · · Int J STD AIDS. · Pubmed #11589797 No free full text.

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Brook MG. · Patrick Clements Clinic, Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK. · J HIV Ther. · Pubmed #14671505 No free full text.

Abstract: The British HIV Association (BHIVA) guidelines on HIV/hepatitis B virus (HBV) and HIV/hepatitis C virus (HCV) co-infection provide comprehensive and up-to-date information on how best to manage this difficult group of patients.

Brook MG. · Patrick Clements Clinic, Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK. · Sex Transm Infect. · Pubmed #12181458 links to  free full text

Abstract: OBJECTIVES: To assess current knowledge of sexually transmitted viral hepatitis in relation to epidemiology, clinical presentation, management, and diagnosis with particular reference to resource-poor settings. METHOD: A search of published literature identified through Medline from 1966 to October 2001, the Cochrane Library, and reference lists taken from each article obtained. Textword and MeSH searches for hepatitis A, B, C, D, E, G, delta, GB virus, GBV-C, and TT virus were linked to searches under the textword terms sex$, prevent$, and MeSH subheadings, microbiology, complications, drug therapy, therapy, diagnosis, epidemiology, transmission, and prevention and control. CONCLUSIONS: In heterosexual relationships, hepatitis B is readily transmitted sexually and hepatitis C and D less so, with no evidence for sexual transmission of hepatitis A. Hepatitis types A-D are all transmissible sexually in male homosexual relationships under certain conditions. In resource-poor countries sexual transmission is generally only a significant route of transmission for hepatitis B.

Obeyesekera S, Jones K, Forster GE, Welch J, Brook MG, Daniels D, Anonymous00400. · Ambrose King Centre, Royal London Hospital, Whitechapel Road, London E1 1BB, UK. · Int J STD AIDS. · Pubmed #17326866 No free full text.

Abstract: A regional audit was undertaken to evaluate current practice in the management of survivors of sexual assault (SA) seen in genitourinary (GU) medicine clinics in the North Thames. The majority of the survivors were women. Most were fast-tracked, or seen in dedicated SA clinics. Over 60% of staff had specific training in management of SA. Core services provided included screening and treatment for sexually transmitted infections, emotional support, emergency contraception and hepatitis B vaccination. The sexual health needs of these survivors of SA are being met by most clinics. The development and use of a standardized care proforma across the region may be a means to further improve the care provided.

de Silva S, Brook MG, Curtis H, Johnson M, Anonymous00102. · Mortimer Market Centre, Capper Street, London WC1E 5AU, UK. · Int J STD AIDS. · Pubmed #17212853 No free full text.

Abstract: The objective of this study is to evaluate the current management practices of patients with HIV and hepatitis B or C co-infection. A postal survey was made of 186 clinics in the UK between October 2003 and January 2004. In total, 100/186 (54%) clinics responded: 16% estimated their hepatitis B prevalence to be above 10%, 27% estimated their hepatitis C to be above 10%. Problems were identified in a minority of clinics including: not routinely screening HIV-positive patients for hepatitis C (6%), restrictions on diagnostic tests required for the management of hepatitis infection and offering inappropriate treatment for hepatitis B infection. The use of diagnostic liver biopsies varied and clinics reported restrictions on access to hepatitis C therapy, with a consequent impact on waiting times. In conclusion, we identified several areas of concern in the diagnosis and management of HIV/hepatitis co-infection in several UK HIV treatment centres.

Brook MG, Curtis H, Johnson MA, Anonymous00325. · Central Middlesex Hospital, NWLH NHS Trust, London, UK. · HIV Med. · Pubmed #15544693 No free full text.

Abstract: OBJECTIVES: To assess the impact of and adherence to the British HIV Association (BHIVA) guidelines in routine clinical practice in the UK and Ireland. METHODS: A self-completed postal survey of practice with regard to HIV management and maternity care of HIV-positive women was carried out. A case-note review of all patients starting their first antiretroviral (ART) therapy (up to a maximum of 25 patients) between April and September 2002 was also performed. RESULTS: A total of 113 treatment centres participated. Ninety-nine units (88%) use the BHIVA ART guidelines as part of their treatment policy. Problems revealed by the survey include limited access to some ARTs in a small number of units and a wait longer than 4 weeks before the first assessment of patients started on ART in some units. Thirty-one centres (33%) felt that their maternity services had reached the government target of >90% antenatal HIV testing by October 2002. A total of 942 case-notes audited showed shortfalls in reported pretreatment testing of blood glucose, lipids and hepatitis C virus. Three patients had not strictly met the BHIVA guidelines for starting ART, but all had a high viral load (>100 000 HIV-1 RNA copies/mL). The majority (844 patients; 90%) had started on recommended therapies, most commonly two nucleoside reverse transcriptase inhibitors and a nonnucleoside reverse transcriptase inhibitor. The other 98 patients (10%) were given a variety of nonstandard triple or quadruple ART. CONCLUSIONS: This audit again shows a high rate of consistency and quality of care of patients with HIV across the UK and Ireland. Problems with pretreatment assessment and early follow up of patients starting ART have been found.

Brook MG, Jones K, Dale AW, Miller RF. · Patrick Clements Clinic, Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK. · Int J STD AIDS. · Pubmed #12869227 No free full text.

Abstract: Our aim was to ascertain current guidelines and clinical practices prevalent in HIV treatment centres in the North Thames Region of England on the care of patients co-infected with HIV and hepatitis B or C. A self-completed postal survey of clinic guidelines and retrospective case-note reviews was performed. Fifteen of the 27 units completed the survey and generally had clinic guidelines consistent with current national guidelines. Stated policy was usually to screen HIV patients for hepatitis B virus (HBV) and hepatitis C virus (HCV) and to offer specific therapy for the hepatitis as well as the HIV. Many units were unable to contribute cases to the case-note review, probably through lack of case-identification, and therefore 11 units contributed 27 case-note reviews on HIV/HBV and five units contributed 11 case-note reviews on HIV/HCV. Fifty-six percent (25/45) of patients of HBV patients were HBeAg+ve and 88% (22/25) of these had received specific hepatitis B therapy although for 59% (13/22) this was with lamivudine as part of a highly active antiretroviral therapy regimen. None of the HIV/HCV patients had received or been referred for HCV-specific therapy. Testing for hepatitis A immunity in HBV or HCV patients with a view to vaccination was done in only 50% although 96% of HIV/HCV patients had been screened for HBV. There are significant differences between the clinics' intended and actual management of HIV and chronic viral hepatitis co-infection.

Brook MG, Rubinstein L, King G. · No affiliation provided · Int J STD AIDS. · Pubmed #18574131 No free full text.

This publication has no abstract.