Hepatitis: Booth JC

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A digest of articles written 1999 and later, on the topic "Hepatitis," originating from Planet Earth —» Booth JC.  Display:  All Citations ·  All Abstracts
1 Guideline Clinical guidelines on the management of hepatitis C. free! 2001

Booth JC, O'Grady J, Neuberger J, Anonymous00102. · Department of Gastroenterology, Royal Berkshire Hospital, London Road, Reading RG5 5AN, UK. · Gut. · Pubmed #11413125 links to  free full text

This publication has no abstract.

2 Article Is hepatitis C virus genotype 4 predominant in Saudi Arabia? 1999

Boriskin YS, Bakir TM, al-Aska AI, Booth JC. · Department of Medical Microbiology, St. George's Hospital Medical School, London, UK. · New Microbiol. · Pubmed #10423734 No free full text.

Abstract: Hepatitis C virus (HCV) genotype 4 is believed to be predominant in the Middle East including Saudi Arabia (SA). We attempted to genotype 80 HCV isolates from different parts of SA by direct sequencing of a variable 222bp fragment from the NS5B region. The phylogenetic analysis of the NS5B sequences was complemented by direct sequence analysis of the conserved 5'-NCR region for HCV type-specific polymorphism. All 80 NS5B sequences separated into 3 clades which comprised 6 type 1b variants, 30 type 4 variants (24 of type 4a and 6 of type 4c or d) and 44 type 3 variants. Apart from two definitive type 3b variants the other 42 type 3 NS5B sequences formed 4 clusters with low similarity to type 3a-f HCV sequences from the database. The precise subtyping of these 42 type 3 variants awaits sequencing of longer HCV RNA stretches. Our results indicate that HCV type 4 may not be the only dominant genotype in SA.