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Definition: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. |
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Synonyms: - Astrocytoma, Grade IV
- Astrocytomas, Grade IV
- Giant Cell Glioblastoma
- Giant Cell Glioblastomas
- Glioblastoma Multiforme
- Glioblastoma, Giant Cell
- Glioblastomas
- Glioblastomas, Giant Cell
- Grade IV Astrocytoma
- Grade IV Astrocytomas
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