GM1 Gangliosidosis

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Is a:
  • Disease or Syndrome
Definition:
An autosomal recessive neurodegenerative disorder caused by the absence or deficiency of beta-galactosidase. It is characterized by intralysosomal accumulation of G(m1) ganglioside and oligosaccharides, primarily in neurons of the central nervous system. The infantile form is characterized by muscle hypotonia, poor psychomotor development, hirsutism, hepatosplenomegaly, and facial abnormalities. The juvenile form features hyperacusis; seizures; and psychomotor retardation. The adult form features progressive dementia; ataxia; and muscle spasticity. (From Menkes, Textbook of Child Neurology, 5th ed, pp96-7)
Synonyms:
  • Beta Galactosidase 1 Deficiency Disease
  • Beta-Galactosidase-1 Deficiency Disease
  • Beta-Galactosidase-1 Deficiency Diseases
  • Deficiency Disease, Beta-Galactosidase-1
  • Deficiency Diseases, Beta-Galactosidase-1
  • Disease, Beta-Galactosidase-1 Deficiency
  • Diseases, Beta-Galactosidase-1 Deficiency
  • G(M1) Gangliosidosis
  • Gangliosidosis G(M1)
  • Gangliosidosis GM1
  • Gangliosidosis GM1, Adult
  • Gangliosidosis GM1, Infantile
  • Gangliosidosis GM1, Juvenile
  • Gangliosidosis GM1, Type 1
  • Gangliosidosis GM1, Type 2
  • Gangliosidosis GM1, Type 3
  • Gangliosidosis, Generalized GM1, Type 1
  • Gangliosidosis, Generalized GM1, Type 2
  • Gangliosidosis, Generalized GM1, Type 3
  • Generalized Gangliosidosis
  • GM1 Gangliosidosis
  • Infantile Gangliosidosis GM1
  • Juvenile Gangliosidosis GM1
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Narrower Topics:
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