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Review Casopitant, a neurokinin-1 receptor antagonist with anti-emetic and anti-nausea activities. 2008
Navari RM. · Indiana University School of Medicine, South Bend, 100 Raclin-Carmichael Hall, South Bend, IN 46617, USA. · Curr Opin Investig Drugs. · Pubmed #18600583 No free full text.
Abstract: Casopitant, an inhibitor of the neurokinin-1 receptor, and its mesylate salt, are being developed by GlaxoSmithKline plc for the potential treatment of chemotherapy-induced nausea and vomiting (CINV), post-operative nausea and vomiting (PONV), as well as for anxiety, depression and insomnia. Phase II trials are ongoing for anxiety, depression and insomnia, and further results are awaited from phase III trials of CINV and PONV. At the time of publication, it was expected that applications to the FDA for regulatory approval for CINV and PONV would be filed in 2008. Casopitant was previously being developed for the treatment of overactive bladder; however, in September 2007, this indication was no longer listed on the company's product pipeline.
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