Fibromyalgia: Dickenson AH

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A digest of articles written 1999 and later, on the topic "Fibromyalgia," originating from Planet Earth —» Dickenson AH.  Display:  All Citations ·  All Abstracts
1 Review Fibromyalgia: harmonizing science with clinical practice considerations. 2008

Perrot S, Dickenson AH, Bennett RM. · Center de la Douleur et Service de Médecine Interne, Hôtel-Dieu, University Paris 5 Descartes, Paris, France. · Pain Pract. · Pubmed #18363616 No free full text.

Abstract: This review summarizes the present and emerging knowledge base on the pathophysiology, diagnosis, and management of fibromyalgia. EPIDEMIOLOGY: Fibromyalgia is the most common chronic pain syndrome encountered in general medicine and rheumatology. Historically, contemporary concepts of fibromyalgia have evolved in terms of its clinical description and parallel advances in the understanding of its pathophysiology. PATHOPHYSIOLOGY: A generally accepted paradigm postulates that fibromyalgia is the clinical expression of a rheumatologic disorder in which the associated pain is driven primarily by central sensitization and possibly through changes in several neuronal systems but not necessarily reliant on peripheral processes. MANAGEMENT: Several agents, including serotonin-norepinephrine reuptake inhibitors (ie, duloxetine and milnacipran), opioids (ie, tramadol), and the alpha2-delta ligand pregabalin, which recently received U.S. regulatory approval for the treatment of fibromyalgia, have been evaluated in clinical trials, demonstrating benefit in terms of pain reduction and improvement in core symptoms (ie, fatigue and sleep disturbance). The European League Against Rheumatism has developed updated guidelines for the management of fibromyalgia.

2 Review Neuropharmacologic targets and agents in fibromyalgia. 2002

Suzuki R, Dickenson AH. · Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom. · Curr Pain Headache Rep. · Pubmed #12095461 No free full text.

Abstract: Chronic widespread pain is a primary feature of fibromyalgia and is a symptom that is poorly managed in many patients. In addition, patients often experience fatigue, sleep disturbances, and anxiety. Its etiology is largely unknown. The successful clinical management of this syndrome relies on a multidisciplinary approach, employing pharmacologic and nonpharmacologic treatments. Clinical evidence on the symptoms and characteristics of fibromyalgia suggests a central mechanism behind the pathogenesis of this syndrome. It is likely that drugs with central actions will prove to be effective against a number of symptoms. This article aims to outline some of the potential spinal pharmacologic targets that may be used to treat this condition.