Crohn Disease: Koletzko S

Hoffmann JC, Preiss JC, Autschbach F, Buhr HJ, Häuser W, Herrlinger K, Höhne W, Koletzko S, Krieglstein CF, Kruis W, Matthes H, Moser G, Reinshagen M, Rogler G, Schreiber S, Schreyer AG, Sido B, Siegmund B, Stallmach A, Bokemeyer B, Stange EF, Zeitz M. · Medizinische Klinik I, St. Marienkrankenhaus, Ludwigshafen. · Z Gastroenterol. · Pubmed #18810679 No free full text.

This publication has no abstract.

Dilger K, Alberer M, Busch A, Enninger A, Behrens R, Koletzko S, Stern M, Beckmann C, Gleiter CH. · Dr Falk Pharma GmbH, Freiburg, Germany. · Aliment Pharmacol Ther. · Pubmed #16422998 No free full text.

Abstract: BACKGROUND: Budesonide is effective as initial therapy of mild to moderate Crohn's disease in adults. Superior tolerability to conventional corticosteroids might be attributed to extensive first-pass metabolism of budesonide by cytochrome P450 3A. AIM: To evaluate biotransformation and pharmacodynamic action of budesonide in children. METHODS: Drug disposition and effects on endogenous cortisol were evaluated in 12 children with Crohn's disease (5-15 years) after first intake of 3 mg budesonide (single dose), and again after 1 week of thrice daily dosing (steady-state). The parent drug and cytochrome P450 3A-dependent metabolites were analysed in blood and urine. RESULTS: Pharmacokinetic parameters of budesonide following single-dose administration (e.g. AUC(0-infinity) 7.7+/-5.1 h ng/mL, C(max) 1.8+/-1.2 ng/mL) did not change upon multiple dosing. Overall systemic elimination of budesonide reflected by clearance and half-life was not different between children and adults. After 1 week of treatment reversible adrenal suppression was observed - most pronounced in children aged below 12 years. CONCLUSIONS: Disposition of oral budesonide appears to be similar between children and adults, but the doctor has to be aware of an increased risk for adrenal suppression in paediatric patients.

Lacher M, Kappler R, Berkholz S, Baurecht H, von Schweinitz D, Koletzko S. · Dr. von Haunersches Kinderspital, Pediatric Surgical Clinic, Research Laboratories, Ludwig-Maximilians-University of Munich, Lindwurmstr 4, D-80337 Munich, Germany. · Biochem Biophys Res Commun. · Pubmed #17892861 No free full text.

Abstract: Genetic and environmental factors contribute to the etiopathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). To identify new susceptibility genes, we determined the mRNA expression level of 88 genes from different biological contexts on colonic biopsies of CD and UC patients. We show that CXCL9 was overexpressed in colonic tissue of 3/5 CD and 3/3 UC patients compared to healthy controls. SNP genotyping for the 77147452G-->A polymorphism of the CXCL9 gene on 114 pediatric IBD patients and 120 ethnically matched unaffected adults detected a minor allele frequency of 20.3% in CD patients compared to 31.3% in controls (p=0.016). Strikingly, children with homozygosity for the wild-type allele had a significant earlier onset of CD than heterozygous individuals (11.1 versus 13.8 years). This is the first report of inverse association of the CXCL9 77147452G-->A polymorphism with pediatric CD. Our data may contribute to a better understanding of the pathophysiology underlying CD.

Radon K, Windstetter D, Poluda AL, Mueller B, von Mutius E, Koletzko S, Anonymous00088. · Unit for Occupational and Environmental Epidemiology & NetTeaching, Institute and Outpatient Clinic for Occupational and Environmental Medicine, Ziemssenstrasse 1, D-80336 Munich, Germany. · Pediatrics. · Pubmed #17671062 links to  free full text

Abstract: OBJECTIVE: The aim of this study was to test the association between farm animal contact in infancy and the development of juvenile Crohn disease and ulcerative colitis. METHODS: A case-control study was conducted in 13 children's hospitals by using a mailed questionnaire. Case subjects with Crohn disease or ulcerative colitis who were registered in these hospitals were eligible (response rate: 90%). Children who underwent strabismus surgery at 11 of the 13 centers served as control subjects (response rate: 85%). All children 6 to 18 years of age who were born in Germany without malformations were included (444 case subjects with Crohn disease, 304 case subjects with ulcerative colitis, and 1481 control subjects). RESULTS: Regular contact with farm animals during the first year of life was associated inversely with Crohn disease and ulcerative colitis. In addition, regular contact with cats in infancy was linked inversely with case status. Allergic rhinitis was correlated significantly with Crohn disease but not with ulcerative colitis. CONCLUSION: Contact with farm environments in infancy might decrease the risk of juvenile Crohn disease and ulcerative colitis.