Coronary Artery Disease: Möhlenkamp S

Oudkerk M, Stillman AE, Halliburton SS, Kalender WA, Möhlenkamp S, McCollough CH, Vliegenthart R, Shaw LJ, Stanford W, Taylor AJ, van Ooijen PM, Wexler L, Raggi P, Anonymous00008, Anonymous00009. · Department of Radiology, Groningen University Hospital, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. · Eur Radiol. · Pubmed #18651153 No free full text.

Abstract: Current guidelines and literature on screening for coronary artery calcium for cardiac risk assessment are reviewed for both general and special populations. It is shown that for both general and special populations a zero score excludes most clinically relevant coronary artery disease. The importance of standardization of coronary artery calcium measurements by multidetector CT is discussed.

Oudkerk M, Stillman AE, Halliburton SS, Kalender WA, Möhlenkamp S, McCollough CH, Vliegenthart R, Shaw LJ, Stanford W, Taylor AJ, van Ooijen PM, Wexler L, Raggi P. · Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. · Int J Cardiovasc Imaging. · Pubmed #18504647 links to  free full text

Abstract: Current guidelines and literature on screening for coronary artery calcium for cardiac risk assessment are reviewed for both general and special populations. It is shown that for both general and special populations a zero score excludes most clinically relevant coronary artery disease. The importance of standardization of coronary artery calcium measurements by multi-detector CT is discussed.

Erbel R, Möhlenkamp S, Kerkhoff G, Budde T, Schmermund A. · Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Hufelandstr 55, D-45122 Essen, Germany. · Heart. · Pubmed #18003695 No free full text.

This publication has no abstract.

Möhlenkamp S, Schmermund A, Budde T, Erbel R. · Cardiologisches Centrum Bethanien (CCB), Frankfurt/Main. · MMW Fortschr Med. · Pubmed #17619604 No free full text.

Abstract: The quantification of coronary calcification facilitates improved prediction of cardiovascular diseases, in particular in persons with intermediate risk. The importance of serial measurement of coronary calcium in one to two-year intervals for evaluating the course of the disease and therapeutic monitoring after risk modification is unclear. The precise quantification of the progression of arteriosclerosis could contribute to the non-invasive detection of the chronic, often subclinical development of coronary heart disease at an asymptomatic stage of the disease, long before an irreversible clinical event in the pathogenetic cascade, such as sudden cardiac death or myocardial infarction, occurs. An important prerequisite for evaluating changes in the coronary calcium load is detailed knowledge of reproducibility or variability. In addition to a rapid image acquisition time and the use of calibration phantoms, low heart rate and breathing variability, image acquisition in the late systole, overlapping layers (at the expense of radiation dose) and optimized analysis algorithms also contribute to improvement in reproducibility. The limits of variability however are, above all, dependent upon the calcium load itself. Reproducibility is on the average about 10% and thus lies below the highest expected progression, which is about 10-50% per year, depending upon the initial value and pre-existing conditions Only a few studies have identified calcium score progression as an independent predictor for later events. In several studies, calcium score progression was related to the rate of events, but was not independent of other variables. The most important determinant appears to be the calcium score itself. Other relevant determinants are age, gender, diabetes, obesity and renal failure. Whether lipid values significantly influence the progression has not been clarified. CONCLUSION: Further studies on the natural course of coronary heart disease, particularly in the early disease stages, the determinants of progression and the extent to which the calcification progress can be modified are necessary to assess the benefit of serial score measurement for risk stratification. Until then, the repeated radiation exposure cannot be recommended outside of clinical studies.

Schmermund A, Möhlenkamp S, Erbel R. · Department of Cardiology, University Clinic Essen, Hufelandstrasse 55, D-45122 Essen, Germany. · Cardiol Clin. · Pubmed #14719566 No free full text.

Abstract: Electron-beam computed tomography (EBCT) and the recent generation of multi-slice computed tomography scanners (MSCT) permit high-resolution imaging of the beating heart and the coronary arteries. The visualization of coronary calcium offers the opportunity to non-invasively obtain direct information on coronary anatomy and plaque burden. For clinical purposes, coronary calcium represents the presence of arteriosclerotic plaques. Coronary calcium is deposited in an actively regulated process related to lipid content of and apoptosis within coronary plaques. The amount of coronary calcium is related to the extent of coronary plaque disease, which has substantial diagnostic and prognostic implications. Visualization of coronary calcium by cardiac CT allows to non-invasively detect and localize coronary plaques and describe their distribution in the coronary tree. Approximately 50% to 70% of all plaques are calcified. Calcium cannot be used to reliably identify plaques at risk for developing complications such as rupture or erosion with ensuing thrombus formation. However, data are accumulating that indicate that calcium is an indicator of coronary arteriosclerotic disease activity. A scan negative for coronary calcium has a high negative predictive value indicating absence of stenotic coronary artery disease and an excellent short- to mid-term prognosis. Studies using serial CT scans indicate that the annual progression of coronary calcium varies between 30% to 50% in symptomatic or high-risk individuals and 0% to 20% in patients treated effectively with lipid-lowering medication. An increased rate of progression of coronary calcium seems to indicate a substantially increased risk for adverse cardiac events.

Möhlenkamp S, Schmermund A, Kerkhoff G, Budde T, Erbel R. · Klinik für Kardiologie Universitätsklinik Essen Hufelandstrasse 55 45122 Essen, Germany. · Z Kardiol. · Pubmed #12966826 No free full text.

Abstract: Non-invasive quantitative indices of atherosclerosis are promising new parameters for an improved prognostic stratification of patients with risk factors that aim at individualized risk factor assessment and modification. In a recently published ACC/AHA consensus document, further data on the diagnostic and prognostic value of coronary calcified plaque quantification were strongly encouraged prior to its use in the general population. In this present work we summarize data published since, which contribute significantly to the prognostic value of fast CT-based noninvasive coronary calcified plaque quantification. It is a measure of atherosclerostic disease activity and is hence an index for the likelihood of future cardiovascular events. Current data indicate that noninvasive quantification of coronary atherosclerosis has incremental prognostic value beyond conventional single risk factor assessment. However, it is not clear yet whether it has a significant value beyond quantitative combined risk assessment using complex risk prediction models such as Framingham charts. Results from ongoing prospective trials such as the MESA study in the US and the Heinz Nixdorf Recall study in Germany will clarify some of the pending issues. In addition, it is still unclear, at what stage of the disease process, which of the available imaging tools will provide optimal diagnostic and prognostic value for the individual patient.

Möhlenkamp S, Schmermund A, Gerber TC, Kerkhoff G, Pump H, Budde T, Erbel R. · Klinik für Kardiologie, Universitätsklinikum Essen, Germany. · Herz. · Pubmed #12669224 No free full text.

Abstract: BACKGROUND: Invasive, selective coronary angiography remains the "gold standard" of direct visualization of epicardial coronary arteries. Technical advances in recent years and improvements in image quality in both electron beam computed tomography (EBT) and multislice spiral/helical computed tomography (MSCT) brought along an increasing interest in the potential clinical role of noninvasive computed tomographic coronary angiography (CTCA). POTENTIAL AND LIMITATIONS: Measurement of coronary calcification permits quantitative estimation of overall coronary plaque burden and thereby allows assessment of cardiovascular risk and likelihood of the presence of a significant stenosis. However, the precise site and degree of stenoses cannot be measured. Contrast-enhanced CTCA lumenography permits visualization of epicardial coronary artery stenoses with a sensitivity and specificity of about 90%. Noncalcified plaques may also be detected in individual cases, but very few data are available on this aspect of CTCA. Image artifacts due to rapid motion, especially in the distal segments of the right and circumflex coronary arteries, may preclude reliable assessment of 20-30% of these segments. Also, in-stent restenoses and distal bypass anastomoses will, in the foreseeable future, remain difficult to confidently diagnose by CTCA. Combined assessment of calcified plaque burden and CTCA may enhance diagnostic accuracy especially in patients with low or moderate calcium scores. In the presence of heavy calcifications, stenoses may be masked. INDICATIONS: Noninvasive CT-based evaluation of coronary arteries seems useful in patients with a low to intermediate pretest likelihood for significant coronary artery disease (CAD). This holds for several ACC/AHA class II indications described for invasive, selective coronary angiography and for few class I indications. Further prospective studies are required to establish the clinical value of combined assessment of coronary calcium quantification and CTCA.

Schmermund A, Möhlenkamp S, Erbel R. · Department of Cardiology, University Clinic Essen, Germany. · Am J Cardiol. · Pubmed #12459420 No free full text.

Abstract: Coronary calcium scanning is no longer restricted to specialized centers but has become widely available as a test that can easily be performed in clinical practice. There have been parallel developments in scientific evaluation of coronary calcium scanning in numerous research studies and the practical use of this test. A number of reports have clarified the relation between the unstable coronary plaque and coronary calcium. Whereas calcium is a frequent feature of plaque rupture, there is too much overlap with more stable plaques to be specific. However, data are accumulating to indicate that calcium is associated with coronary atherosclerotic disease activity. Indeed, reports presented within the past year have demonstrated that very high calcium scores, in particular those >1,000, indicate a significantly increased cardiovascular risk. The advent of cardiac spiral computed tomography (CT) has made coronary calcium scanning widely available. As this methodology is continuously evolving, a number of challenges regarding standardization of test ordering, performance, and interpretation have arisen. Currently, 4-slice spiral CT scanners are most widely used. Protocols with prospective or retrospective electrocardiographic triggering are used, which appear to yield results similar to the Agatston coronary calcium score compared with electron-beam CT, despite the technical differences. New scoring algorithms are being evaluated. With electron-beam and spiral CT we have, for the first time, a readily available test for direct diagnostic visualization of the coronary arteries in clinical practice. This represents the opportunity and the challenge of a proof of principle.

Möhlenkamp S, Hort W, Ge J, Erbel R. · Clinic of Cardiology, University Clinic Essen, Germany. · Circulation. · Pubmed #12427660 links to  free full text

This publication has no abstract.

Erbel R, Schmermund A, Möhlenkamp S, Sack S, Baumgart D. · Department of Cardiology, Division of Internal Medicine, University Clinic Essen, Germany. · Eur Heart J. · Pubmed #10739727 links to  free full text

This publication has no abstract.

Erbel R, Möhlenkamp S, Jöckel KH, Lehmann N, Moebus S, Hoffmann B, Schmermund A, Stang A, Siegrist J, Dragano N, Grönemeyer D, Seibel R, Mann K, Bröcker-Preuss M, Kröger K, Volbracht L. · No affiliation provided · Dtsch Arztebl Int. · Pubmed #19578446 links to  free full text

Abstract: INTRODUCTION: Modern investigation modalities allow markers of atherosclerosis to be detected at a subclinical stage. The aim of the study was to analyze the prevalence of these markers in relation to traditional risk factors. METHODS: The population based study included 4814 participants, aged 45 to 75 years, with a response rate of 55.8% of those contacted. The patients' history, psychosocial and environmental risk factors were assessed. RESULTS: The prevalence of obesity was 26.2% in men and 28.1% in women, 26% of men and 21% of women were smokers. Hypertension was found in 46% of men and 31% of women, diabetes in 9.3% of men and 6.3% of women. Markers of subclinical peripheral arterial disease were found in 6.4% of men and 5.1% of women, of subclinical carotid artery disease in 43.2% and 30.7%, and of subclinical coronary artery calcification in 82.3% and 55.2%, respectively. The prevalence of coronary calcification measured using an Agatston Score >100 was in 40% in men and 15% in women, using a score >400, 16.8% and 4.5%, respectively. DISCUSSION: A high prevalence of subclinical atherosclerosis was found in the older population. The follow-up period will demonstrate whether the detection of markers of subclinical atherosclerosis will improve risk stratification beyond that offered by traditional risk factors.

Breuckmann F, Möhlenkamp S, Nassenstein K, Lehmann N, Ladd S, Schmermund A, Sievers B, Schlosser T, Jöckel KH, Heusch G, Erbel R, Barkhausen J. · Department of Cardiology, West German Heart Center Essen, Essen, Germany. · Radiology. · Pubmed #19332846 No free full text.

Abstract: PURPOSE: To prospectively analyze the myocardial distribution of late gadolinium enhancement (LGE) with delayed-enhancement cardiac magnetic resonance (MR) imaging, to compare the prevalence of this distribution in nonprofessional male marathon runners with that in asymptomatic control subjects, and to examine the prognostic role of LGE. MATERIALS AND METHODS: Institutional review board and ethics committee approval were obtained for this study, and all subjects provided written informed consent. Two-dimensional inversion-recovery segmented k-space gradient-echo MR sequences were performed after administration of a gadolinium-containing contrast agent in 102 ostensibly healthy male runners aged 50-72 years who had completed at least five marathons during the past 3 years and in 102 age-matched control subjects. Predominantly subendocardial regions of LGE typical of myocardial infarction (hereafter, coronary artery disease [CAD] pattern) were distinguished from a predominantly midmyocardial patchy pattern of LGE (hereafter, non-CAD pattern). Marathon runners with LGE underwent repeat cardiac MR imaging and additional adenosine perfusion imaging. Runners were followed up for a mean of 21 months +/- 3 (standard deviation) after initial presentation. The chi(2), Fisher exact, and McNemar exact tests were used for comparisons. Event-free survival rates were estimated with the Kaplan-Meier method, and overall group differences were evaluated with log-rank statistics. RESULTS: Of the 102 runners, five had a CAD pattern of LGE, and seven had a non-CAD pattern of LGE. The CAD pattern of LGE was located in the territory of the left anterior descending coronary artery more frequently than was the non-CAD pattern (P = .0027, Fisher exact test). The prevalence of LGE in runners was higher than that in age-matched control subjects (12% vs 4%; P = .077, McNemar exact test). The event-free survival rate was lower in runners with myocardial LGE than in those without myocardial LGE (P < .0001, log-rank test). CONCLUSION: Ostensibly healthy marathon runners have an unexpectedly high rate of myocardial LGE, and this may have diagnostic and prognostic relevance.

Moebus S, Stang A, Möhlenkamp S, Dragano N, Schmermund A, Slomiany U, Hoffmann B, Bauer M, Broecker-Preuss M, Mann K, Siegrist J, Erbel R, Jöckel KH, Anonymous00023. · Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany. · Diabetologia. · Pubmed #18979083 No free full text.

Abstract: AIMS/HYPOTHESIS: Atherosclerosis and cardiovascular diseases are often present at the time of diagnosis of type 2 diabetes mellitus. Whether subclinical atherosclerosis can be detected in the pre-diabetic (borderline fasting hyperglycemia) state is not clear. This study investigated the association of impaired fasting glucose (IFG) and coronary artery calcification (CAC), a marker of subclinical atherosclerosis, among participants without a history of coronary heart disease or manifest diabetes mellitus. METHODS: Study participants (aged 45-75 years) of the population-based Heinz Nixdorf Recall Study were categorised into those with normal fasting glucose (glucose <6.1 mmol/l) and those with IFG (glucose >or=6.1 to <7.0 mmol/l), excluding participants with a history of CHD or diabetes mellitus. CAC was assessed by electron-beam computed tomography, and risk factors were assessed by extended interviews, anthropometric measurements and laboratory tests. Various CAC cut-off points were used in multiple logistic and ordinal logistic regression models to estimate ORs and 95% CIs. RESULTS: Of the 2,184 participants, more men had IFG than did women (37% vs 22%). Participants with IFG showed a higher prevalence of CAC > 0 (men OR 1.90, 95% CI 1.33-2.70; women 1.63, 1.23-2.15). Risk factor adjustment weakened this association in both sexes (men 1.63, 1.12-1.36; women 1.26, 0.93-1.70). When the age- and sex-specific 75th percentile was used as the cut-off point for CAC, the association further decreased in men (1.10, 0.81-1.50), but became stronger in women (1.41, 1.02-1.94). CONCLUSIONS/INTERPRETATION: These data support the hypothesis that CAC is already present in the pre-diabetic state and that IFG has a modest and independent impact on the atherosclerotic process. Biological sex appears to modify the association between IFG and CAC.

Dragano N, Hoffmann B, Stang A, Moebus S, Verde PE, Weyers S, Möhlenkamp S, Schmermund A, Mann K, Jöckel KH, Erbel R, Siegrist J, Anonymous00028. · Department of Medical Sociology, Heinrich-Heine-University, PO 101007, Duesseldorf 40001, Germany. · Eur J Epidemiol. · Pubmed #18931923 No free full text.

Abstract: Inhabitants of deprived neighbourhoods are at higher risk of coronary heart disease. In this study we investigate the hypothesis that social inequalities at neighbourhood level become already manifest in subclinical coronary atherosclerosis, as defined by electron-beam computed tomography derived measures. Coronary artery calcification was assessed as a marker of atherosclerosis in a population based sample of 4301 men and women (45-75 years) without a history of coronary heart disease. Participants lived in three adjacent cities in Germany and were examined between 2000 and 2003 as part of the Heinz Nixdorf Recall Study. Individual level data was combined with neighbourhood level information about unemployment, welfare and living space per inhabitant. This dataset was analysed with descriptive and multilevel regression methods. An association between neighbourhood deprivation and subclinical coronary calcification was observed. After adjustment for age and individual socioeconomic status male inhabitants of high unemployment neighbourhoods had an odds ratio of 1.45 (1.11, 1.96) of exhibiting a high calcification score (>75th percentile) compared to men living in low unemployment areas. The respective odds for women was 1.29 (0.97, 1.70). Additional explorative analyses suggest that clustering of unhealthy lifestyles in deprived neighbourhoods contributes to the observed association. In conclusion, findings suggest that certain neighbourhood characteristics promote the emergence of coronary atherosclerosis. This might point to a pathway from neighbourhood deprivation to manifest coronary heart disease.

Erbel R, Delaney JA, Lehmann N, McClelland RL, Möhlenkamp S, Kronmal RA, Schmermund A, Moebus S, Dragano N, Stang A, Jöckel KH, Budoff MJ, Anonymous00025, Anonymous00026. · Department of Cardiology, University of Duisburg-Essen, Essen, Germany. · Eur Heart J. · Pubmed #18845666 links to  free full text

Abstract: AIMS: Modern imaging technology allows us the visualization of coronary artery calcification (CAC), a marker of subclinical coronary atherosclerosis. The prevalence, quantity, and risk factors for CAC were compared between two studies with similar imaging protocols but different source populations: the Multi-Ethnic Study of Atherosclerosis (MESA) and the Heinz Nixdorf Recall Study (HNR). METHODS AND RESULTS: The measured CAC in 2220 MESA participants were compared with those in 3,126 HNR participants with the inclusion criteria such as age 45-75 years, Caucasian race, and free of baseline cardiovascular disease. Despite similar mean levels of CAC of 244.6 among participants in MESA and of 240.3 in HNR (P = 0.91), the prevalence of CAC > 0 was lower in MESA (52.6%) compared with HNR (67.0%) with a prevalence rate ratio of CAC > 0 of 0.78 [95% confidence interval (CI): 0.72-0.85] after adjustment for known risk factors. Consequently, among participants with CAC > 0, the participants in MESA tended to have higher levels of CAC than those in HNR (ratio of CAC levels: 1.39; 95% CI: 1.19-1.63), since many HNR participants have small (near zero) CAC values. CONCLUSIONS: The CAC prevalence was lower in the United States (MESA) cohort than in the German (HNR) cohort, which may be explained by more favourable risk factor levels among the MESA participants. The predictors for increased levels of CAC were, however, similar in both cohorts with the exception that male gender, blood pressure, and body mass index were more strongly associated in the HNR cohort.

Böse D, von Birgelen C, Zhou XY, Schmermund A, Philipp S, Sack S, Konorza T, Möhlenkamp S, Leineweber K, Kleinbongard P, Wijns W, Heusch G, Erbel R. · Dept. of Cardiology, West German Heart Center, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany. · Basic Res Cardiol. · Pubmed #18787802 No free full text.

Abstract: BACKGROUND: Cardiac marker release after percutaneous coronary interventions (PCI) reflects myocardial necrosis which is usually the result of periprocedural (micro)embolization of atherothrombotic debris and associated with impaired left ventricular function and adverse outcome. METHODS: In this prospective study, we examined 55 patients treated by direct stenting of single de-novo lesions to assess the relationship between plaque composition, as determined by preinterventional intravascular ultrasound (IVUS) with radiofrequency data (IVUS-RF) analysis (so-called Virtual Histology) versus coronary microembolization, as determined by serial measurement of cardiac markers. IVUS was performed with an electronic system and 20-MHz IVUS catheters. Serum creatine kinase (CK) and cardiac troponin I (CTnI) were determined before PCI and after 6, 12, and 24 hours. RESULTS: Plaques had a volume of 99 +/- 63 mm(3) and were composed of fibrous (61 +/- 9%) and fibro-fatty tissue (27 +/- 12%), dense calcium (4 +/- 3%), and necrotic core (NC) (8 +/- 6%). NC volume per se, volume per 10 mm of segment length, and volume % were correlated (r = 0.64, 0.66, and 0.52 respectively; all P < 0.01) with the maximum increase in cardiac markers (CK 55.4 +/- 55.7 U/l; CTnI 0.49 +/- 0.68 ng/ml). Patients in the 4th quartile of NC volume (>10.8 mm(3)) had a particularly high increase in markers (P < 0.001). In contrast, total plaque volume and plaque components other than NC had no relation with cardiac markers (ns). CONCLUSIONS: Patients with large NC in culprit lesions may experience more myocardial injury from peri-interventional microembolization. IVUS-RF assessment before PCI has the potential to identify lesions at particular high risk which may help to tailor PCI.

Nassenstein K, Breuckmann F, Lehmann N, Schmermund A, Hunold P, Broecker-Preuss M, Sandner TA, Halle M, Mann K, Jöckel KH, Heusch G, Budde T, Erbel R, Barkhausen J, Möhlenkamp S. · Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, Essen, Germany. · Int J Cardiovasc Imaging. · Pubmed #18677576 No free full text.

Abstract: BACKGROUND: To assess left ventricular volumes and mass by cardiac magnetic resonance imaging in relation to conventional cardiovascular risk factors and coronary atherosclerotic plaque burden in master marathon runners aged > or =50 years. METHODS: Cardiac MRI was performed in 105 clinically healthy male marathon runners (mean age 57.3 +/- 5.7 years, range 50-71 years) on a 1.5 T MR system (Avanto, Siemens, Germany). Cine steady state free precession images in standard long and short axes views were acquired to assess left ventricular volumes and mass. Cardiovascular risk factors (blood pressure, HDL/LDL cholesterol, smoking, body mass index) were assessed and coronary artery calcification (CAC) was quantified by electron beam computed tomography. RESULTS: Left ventricular muscle mass (mean LVMM = 140 +/- 27 g; 73 +/- 13 g/m(2)) increased with increasing left ventricular end-diastolic volume (mean LVEDV = 137 +/- 32 ml; 72 +/- 15 ml/m(2)) (r = 0.41, P < 0.0001) and with systolic (r = 0.33, P = 0.005) and diastolic (r = 0.28, P = 0.005) blood pressures. Left ventricular EDV increased up to the age of 55 years, but decreased thereafter. Runners with LVMM > or =150 g had significantly higher CAC scores than runners with LVMM <150 g (median CAC score 110 vs. 25, P = 0.04). CONCLUSIONS: Increases in LVMM and LVEDV may not only represent a response to exercise but are dependent on age and blood pressure, also. In addition, a left ventricular hypertrophy without an increase in volume may be an indicator for early subclinical cardiac alterations in response to risk factor exposure.

Jöckel KH, Lehmann N, Jaeger BR, Moebus S, Möhlenkamp S, Schmermund A, Dragano N, Stang A, Grönemeyer D, Seibel R, Mann K, Volbracht L, Siegrist J, Erbel R. · Institute for Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Germany. · Atherosclerosis. · Pubmed #18602109 No free full text.

Abstract: BACKGROUND: Smoking accounts for more than 5 million years of potential life lost per year in the US alone. Leading causes of smoking attributable mortality are acute atherothrombotic complications of coronary heart disease (CHD). Smoking cessation is a key issue in preventive medicine, but quantitative data on its benefit for the coronary arteries are sparse. METHODS: The Heinz Nixdorf Recall Study is an ongoing population-based, prospective cohort study, with 4814 participants aged 45-74 years (49.8% men). Baseline data of 4078 participants without history of established coronary heart disease or stroke are included in this report. Electron beam-computed tomography allows for non-invasive quantification of coronary artery calcium (CAC). We estimate the risk-related ageing of coronary arteries from multivariable regression of CAC on smoking behavior, sex, age and risk factors. RESULTS: Smoking 20 cigarettes per day since the age of 16 is associated with a CAC burden which is found in a person 10 years older who has never smoked (both sexes). Smoking cessation at 45, 55 or 65 leads to CAC at the age of 75 that would have been reached 9, 6 or 3 years earlier, respectively, had smoking been continued. CONCLUSIONS: In individuals without overt CHD, present smokers are about 10 years older in 'coronary artery age' than never smokers. The accumulation of CAC is accelerated by smoking and slows down after smoking cessation, but advanced CAC is persistent for a long period. These quantitative findings strongly support smoking cessation measures as early as possible, to prevent accelerated arterial ageing.

Möhlenkamp S, Lehmann N, Breuckmann F, Bröcker-Preuss M, Nassenstein K, Halle M, Budde T, Mann K, Barkhausen J, Heusch G, Jöckel KH, Erbel R, Anonymous00005, Anonymous00006. · Clinic of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. · Eur Heart J. · Pubmed #18426850 links to  free full text

Abstract: AIMS: To quantify the prevalence of coronary artery calcification (CAC) in relation to cardiovascular risk factors in marathon runners, and to study its role for myocardial damage and coronary events. METHODS AND RESULTS: In 108 apparently healthy male marathon runners aged >or=50 years, with >or=5 marathon competitions during the previous three years, the running history, Framingham risk score (FRS), CAC, and presence of myocardial late gadolinium enhancement (LGE) were measured. Control groups were matched by age (8:1) and FRS (2:1) from the Heinz Nixdorf Recall Study. The FRS in marathon runners was lower than in age-matched controls (7 vs. 11%, P < 0.0001). However, the CAC distribution was similar in marathon runners and age-matched controls (median CAC: 36 vs. 38, P = 0.36) and higher in marathon runners than in FRS-matched controls (median CAC: 36 vs. 12, P = 0.02). CAC percentile values and number of marathons independently predicted the presence of LGE (prevalence = 12%) (P = 0.02 for both). During follow-up after 21.3 +/- 2.8 months, four runners with CAC >or= 100 experienced coronary events. Event-free survival was inversely related to CAC burden (P = 0.018). CONCLUSION: Conventional cardiovascular risk stratification underestimates the CAC burden in presumably healthy marathon runners. As CAC burden and frequent marathon running seem to correlate with subclinical myocardial damage, an increased awareness of a potentially higher than anticipated coronary risk is warranted.

Stang A, Dragano N, Poole C, Moebus S, Möhlenkamp S, Schmermund A, Siegrist J, Erbel R, Jöckel KH. · Clinical Epidemiology Unit, Institute of Medical Epidemiology, Biometry and Informatics, Medical Faculty, University of Halle-Wittenberg, Halle, Germany. · Sleep. · Pubmed #17910383 links to  free full text

Abstract: BACKGROUND: Several studies have assessed the association between siesta and cardiovascular outcomes. Concern exists that confounding might have distorted these results and contributed to discrepancies among them. This report examines the association between siesta habits and cardiovascular risk factors, including sleep disturbances at night, depressed mood, and measures of subclinical atherosclerosis such as coronary calcium score and ankle brachial index. METHODS: The baseline examination of 4,797 participants aged 45-74 years included interviews, physical examinations, laboratory tests, and electron beam computed tomography. We compared the baseline prevalence of depressed mood, nighttime sleep disturbances, and health status in 3 categories of siesta habits: irregular or no siestas; daily short siestas (1 hour or less); and daily long siestas (>1 hour). We also characterized cardiovascular risk factor distributions in the 3 siesta groups and conducted a sensitivity analysis of the potential for confounding by these factors in studies of incident cardiovascular disease. RESULTS: Depressed mood and poor self-perceived health status at baseline had positive associations with the age-standardized prevalence of daily long siestas among both men and women. Daily takers of long siestas had a considerably higher prevalence of cardiovascular risk factors in both sexes and appreciably worse measures of subclinical atherosclerosis in men only, in comparison with either of the other siesta groups. Daily long siestas had positive associations with prevalence of several cardiovascular risk factors and measures of subclinical atherosclerosis. CONCLUSIONS: If uncontrolled, these associations could produce appreciable confounding in studies of siesta habits and incidence of cardiovascular events.

Möhlenkamp S, Erbel R. · Stefan Möhlenkamp Klinik für Kardiologie, Westdeutsches Herzzentrum Essen, Uniklinik Duisburg-Essen. · MMW Fortschr Med. · Pubmed #17668761 No free full text.

Abstract: Coronary calcification is a measure of the extent of coronary stenosis. The aim of a quantification of coronary calcification in asymptomatic persons is to improve the stratification of the cardiovascular risk. A number of studies have shown that a high coronary calcium score is associated with an elevated cardiovascular risk. Furthermore, it has recently been shown that the quantification of coronary calcification can be employed to improve the prediction of cardiovascular events in comparison with conventional risk stratification, in particular in persons carrying an intermediate risk. The applicability of these results to the general population is currently being investigated in the Heinz-Nixdorf Recall Study.

Dragano N, Verde PE, Moebus S, Stang A, Schmermund A, Roggenbuck U, Möhlenkamp S, Peter R, Jöckel KH, Erbel R, Siegrist J, Anonymous00032. · Department of Medical Sociology, University Clinic Düsseldorf, West-German Heart Center Essen, University Duisburg-Essen, Germany. · Eur J Cardiovasc Prev Rehabil. · Pubmed #17667649 No free full text.

Abstract: BACKGROUND: Social inequalities of manifest coronary heart diseases are well documented in modern societies. Less evidence is available on subclinical atherosclerotic disease despite the opportunity to investigate processes underlying this association. Therefore, we examined the relationship between coronary artery calcification as a sign of subclinical coronary atherosclerosis, socio-economic status and established cardiovascular risk factors in a healthy population. DESIGN: Cross-sectional. METHODS: In a population-based sample of 4487 men and women coronary artery calcification was assessed by electron beam computed tomography quantified by the Agatston score. Socio-economic status was assessed by two indicators, education and income. First, we investigated associations between the social measures and calcification. Second, we assessed the influence of cardiovascular risk factors on this association. RESULTS: After adjustment for age, men with 10 and less years of formal education had a 70% increase in calcification score compared with men with high education. The respective increase for women was 80%. For income the association was weaker (among men 20% higher for the lowest compared with the highest quartile; and among women 50% higher, respectively). Consecutive adjustment for cardiovascular risk factors significantly attenuated the observed association of socio-economic status with calcification. CONCLUSIONS: Social inequalities in coronary heart diseases seem to influence signs of subclinical coronary atherosclerosis as measured by coronary artery calcification. Importantly, cumulation of major cardiovascular risk factors in lower socio-economic groups accounted for a substantial part of this association.

Hoffmann B, Moebus S, Möhlenkamp S, Stang A, Lehmann N, Dragano N, Schmermund A, Memmesheimer M, Mann K, Erbel R, Jöckel KH, Anonymous00356. · Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany. · Circulation. · Pubmed #17638927 links to  free full text

Abstract: BACKGROUND: Long-term exposure to fine-particulate-matter (PM2.5) air pollution may accelerate the development and progression of atherosclerosis. We investigated the associations of long-term residential exposure to traffic and fine particulate matter with the degree of coronary atherosclerosis. METHODS AND RESULTS: We used baseline data on 4494 participants (age 45 to 74 years) from the German Heinz Nixdorf Recall Study, a population-based, prospective cohort study that started in 2000. To assess exposure differences, distances between residences and major roads were calculated, and annual fine particulate matter concentrations, derived from a small-scale dispersion model, were assigned to each address. The main outcome was coronary artery calcification (CAC) assessed by electron-beam computed tomography. We evaluated the association between air pollution and CAC with logistic and linear regression analyses, controlling for individual level risk factors of coronary atherosclerosis. Compared with participants living >200 m away from a major road, participants living within 50, 51 to 100, and 101 to 200 m had odds ratios of 1.63 (95% CI, 1.14 to 2.33), 1.34 (95% CI, 1.00 to 1.79), and 1.08 (95% CI, 0.85 to 1.39), respectively, for a high CAC (CAC above the age- and gender-specific 75th percentile). A reduction in the distance between the residence and a major road by half was associated with a 7.0% (95% CI, 0.1 to 14.4) higher CAC. Fine particulate matter exposure was associated with CAC only in subjects who had not been working full-time for at least 5 years. CONCLUSIONS: Long-term residential exposure to high traffic is associated with the degree of coronary atherosclerosis.

Möhlenkamp S, Böse D, Mahabadi AA, Heusch G, Erbel R. · West German Heart Center Essen, Clinic of Cardiology, University Clinic Duisburg-Essen, Essen, Germany. · Nat Clin Pract Cardiovasc Med. · Pubmed #17589430 No free full text.

Abstract: BACKGROUND: An asymptomatic and apparently healthy 64-year-old marathon runner underwent comprehensive cardiovascular risk assessment as part of a prospective study on calcified coronary plaque burden in master marathon runners. His profile suggested a low 10-year cardiovascular risk. INVESTIGATIONS: Conventional risk-factor assessment, coronary artery calcium quantification, bicycle stress test, echocardiography, coronary angiography, intravascular ultrasonography, including virtual histology, and intracoronary Doppler ultrasonography. DIAGNOSIS: Severe coronary atherosclerosis of the left anterior descending, mid left circumflex, and left main arteries. MANAGEMENT: Stenting of the left anterior descending artery, CABG surgery, and intensive risk-factor modification. The patient was also advised against participating in future marathon competitions.

Schmermund A, Lehmann N, Bielak LF, Yu P, Sheedy PF, Cassidy-Bushrow AE, Turner ST, Moebus S, Möhlenkamp S, Stang A, Mann K, Jöckel KH, Erbel R, Peyser PA. · Department of Cardiology, University Clinic Essen, Germany. · Atherosclerosis. · Pubmed #17532322 links to  free full text

Abstract: BACKGROUND: On the basis of the Framingham risk algorithm, overestimation of clinical events has been reported in some European populations. Electron-beam computed tomography-derived quantification of coronary artery calcification (CAC) allows for non-invasive assessment of coronary atherosclerosis in the general population and may thus add important in vivo information on the path from risk factor exposure to formation of clinical events. The current study was undertaken to compare the relationship between risk factors and subclinical coronary atherosclerosis between non-Hispanic white cohorts in Germany and US-America, the hypothesis being that subclinical coronary atherosclerosis might be less prevalent in Europe at the same level of classical risk factor exposure. METHODS: The Heinz Nixdorf Recall (HNR) study, conducted in the German Ruhr area and the Epidemiology of Coronary Calcification (ECAC) study, conducted in Olmsted County, Minnesota, both recruited large unselected cohorts, men and women aged 45-74 years, from the general population. All subjects with no history of coronary artery disease (CAD) or stroke were included (n=3120 in HNR, n=703 in ECAC). Coronary risk factors were assessed by personal and computer-assisted interviews and direct laboratory measurements. Cardiovascular medication use (antihypertensive, lipid-lowering, and anti-diabetic) was noted. CAC scores were determined using the Agatston method in an identical fashion in both studies. RESULTS: Adverse levels of risk factors were more prevalent, and the Framingham risk score was higher (10.6+/-7.6 versus 9.3+/-7.1, p<0.001) in HNR than ECAC, respectively. There was no difference in body mass index (BMI). CAC scores were greater in HNR than in ECAC (mean values, 155.7+/-423.0 versus 107.2+/-280.0; median values, 11.9 versus 2.4; p<0.001, respectively). When subjects were matched on CAD risk factors, presence and quantity of CAC were similar in the 2 cohorts. Risk factors significantly associated with CAC score in both studies included: age, male sex, current and former smoking, systolic blood pressure, and non-HDL-cholesterol. Inferences were similar after excluding subjects using lipid- or blood pressure-lowering medications. Using the same risk factor variables for modelling, the predicted CAC scores were comparable in both cohorts. CONCLUSIONS: In the higher-risk German cohort, presence and quantity of CAC were greater than in the lower-risk US-American cohort. Risk factor associations with CAC were very similar in both unselected populations. We could not demonstrate a relative increase in subclinical coronary atherosclerosis in the US-American cohort. It appears possible to compare CAC as a measure of subclinical coronary artery disease in different populations on different continents, and accordingly, scanning guidelines might be translated across these populations.