Hereditary Nonpolyposis Colorectal Neoplasms

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Is a:
  • Neoplastic Process
Definition:
A group of autosomal-dominant inherited diseases in which colon cancer arises in discrete adenomas. Unlike familial polyposis coli with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. hnpcc has been associated with germline mutations in mismatch repair (mmr) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and lynch syndrome ii which includes extracolonic cancer. hnpcc with no history of associated cancers.
Synonyms:
  • Colon Cancer, Familial Nonpolyposis
  • Hereditary Nonpolyposis Colorectal Cancer
  • Hereditary Nonpolyposis Colorectal Neoplasms
  • Lynch Cancer Family Syndrome I
  • Lynch Syndrome
  • Lynch Syndrome I
  • Syndrome, Lynch
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