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Review Ultrasonography of chronic inflammatory bowel diseases. 2001
Valette PJ, Rioux M, Pilleul F, Saurin JC, Fouque P, Henry L. · Service de radiologie, pavillon H, Fédération des Spécialités Digestives, Hôpital Edouard Herriot, place d'Arsonval, 69003 Lyon, France. · Eur Radiol. · Pubmed #11702118 No free full text.
Abstract: Advances in the understanding of bowel appearances with high-resolution sonography have led to consideration of this technique as an important tool for bowel disease assessment. Ultrasonography may display the transformation of the intestinal wall from normal to pathological state in inflammatory diseases. Furthermore, intestinal ultrasonography may serve as a diagnostic clue if typical patterns of the bowel wall are demonstrated. Thus, Crohn's disease, ulcerative colitis, diverticulitis, or infectious ileocolitis may be specifically demonstrated in the majority of cases. Besides showing the parietal signs of inflammation, ultrasonography also shows the perigut abnormalities and may demonstrate complications such as fistulas and abscesses. Finally, with the help of Doppler, some additional information may be obtained about the activity of chronic inflammatory diseases. In clinical practice, used in combination with other imaging modalities, such as CT or endoscopy, bowel ultrasonography appears to be a non-invasive and effective diagnostic tool for the diagnosis and follow-up of Crohn's disease and ulcerative colitis.
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Article [Pancytopenia induced by two low-dose injections of methotrexate in a patient treated for ulcerative colitis] 2007
Chalumeau S, Moussata D, Nancey S, Claudel-Bonvoisin S, Saurin JC, Flourié B. · Service d'hépatogastroentérologie, Centre hospitalier Lyon-Sud, Pierre-Bénite. · Gastroenterol Clin Biol. · Pubmed #18176366 No free full text.
Abstract: A 72 year-old man with steroid-dependent ulcerative colitis was treated with methotrexate at 25 mg subcutaneous weekly. Three days after the second injection of methotrexate a pancytopenia occurred associated with a Klebsiella pneumoniae septicemia which evolution was favourable under treatment. Pancytopenia is a rare but severe adverse effect of low-dose methotrexate therapy. In our patient the risk factors were age upper than 65 years, renal insufficiency and hypoalbuminemia. This report emphasizes the need for a close monitoring of hematologic tests after onset of methotrexate particularly if some risk factors are present.
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