Ulcerative Colitis: Claudel-Bonvoisin S

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A digest of articles written 1999 and later, on the topic "Colitis, Ulcerative," originating from Planet Earth —» Claudel-Bonvoisin S.  Display:  All Citations ·  All Abstracts
1 Article [Pancytopenia induced by two low-dose injections of methotrexate in a patient treated for ulcerative colitis] 2007

Chalumeau S, Moussata D, Nancey S, Claudel-Bonvoisin S, Saurin JC, Flourié B. · Service d'hépatogastroentérologie, Centre hospitalier Lyon-Sud, Pierre-Bénite. · Gastroenterol Clin Biol. · Pubmed #18176366 No free full text.

Abstract: A 72 year-old man with steroid-dependent ulcerative colitis was treated with methotrexate at 25 mg subcutaneous weekly. Three days after the second injection of methotrexate a pancytopenia occurred associated with a Klebsiella pneumoniae septicemia which evolution was favourable under treatment. Pancytopenia is a rare but severe adverse effect of low-dose methotrexate therapy. In our patient the risk factors were age upper than 65 years, renal insufficiency and hypoalbuminemia. This report emphasizes the need for a close monitoring of hematologic tests after onset of methotrexate particularly if some risk factors are present.