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Article Pseudoporphyria and nonsteroidal antiinflammatory agents in children with juvenile idiopathic arthritis. 2000
De Silva B, Banney L, Uttley W, Luqmani R, Schofield O. · Department of Dermatology, Royal Infirmary of Edinburgh, and Department of Paediatric Rheumatology, Royal Hospital for Sick Children, Edinburgh, Scotland. BDeS2.excite.com · Pediatr Dermatol. · Pubmed #11123786 No free full text.
Abstract: Pseudoporphyria is characterized by erythema, blistering, and scarring on sun-exposed skin. Nonsteroidal antiinflammatory drugs (NSAIDs) are implicated in the etiology of this condition. In a 1-year prospective study of children attending the pediatric rheumatology clinic in Edinburgh we found a prevalence of pseudoporphyria of 10.9% in children taking NSAIDs for juvenile idiopathic arthritis. Naproxen was the most commonly implicated NSAID, independent of dosage. Blue/gray eye color was an independent risk factor for the development of pseudoporphyria. We would advise caution in prescribing naproxen in these children to prevent disfiguring facial scarring.
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