Rheumatoid Arthritis: Sokolowski N

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A digest of articles written 1999 and later, on the topic "Arthritis, Rheumatoid," originating from Planet Earth —» Sokolowski N.  Display:  All Citations ·  All Abstracts
1 Review The involvement of the liver in systemic diseases. 2008

Malnick S, Melzer E, Sokolowski N, Basevitz A. · Department of Internal Medicine, Institute of Gastroenterology , Kaplan Medical Center, Rehovot, Israel. · J Clin Gastroenterol. · Pubmed #18097294 No free full text.

Abstract: The liver has a double blood supply and plays a central role in the metabolism of proteins, carbohydrates, and many medications. In addition, it has a role in the induction of immune tolerance and may also be a target for immune-mediated damage. For these reasons, the liver may be involved in many systemic diseases. In this review, we discuss the involvement of the liver in granulomatous, rheumatologic, malignant, and circulatory diseases. An understanding of the wide spectrum of liver involvement in systemic diseases will aid in both diagnosis and treatment of patients with a wide range of medical conditions.

2 Review Granulomatous hepatitis and Sjogren's syndrome: an association. 2006

Miller EB, Shichmanter R, Friedman JA, Sokolowski N. · Department of Internal Medicine D, Consulting Rheumatologist, Rheumatology Unit, Israel. · Semin Arthritis Rheum. · Pubmed #16970979 No free full text.

Abstract: BACKGROUND: Sjogren's syndrome (SS) is a common autoimmune disorder in which liver involvement is frequent, but generally mild and subclinical. Multiple hepatic histologies have been reported, but to our knowledge an association with granulomatous hepatitis (GH) has never been described. We recently evaluated an individual in whom biopsy-proven GH was associated with concomitant SS. OBJECTIVE: To clarify the possible association between GH and SS. METHODS: We retrospectively reviewed all cases of biopsy-proven GH seen in our institution from 1991 to 2004. Overall, there were 16 individuals with GH identified of which 4 were considered idiopathic in origin. These individuals underwent an extensive evaluation for the presence of SS as well as other disorders known to be associated with GH. RESULTS: Of the 4 identified cases with a previously suspected idiopathic GH, 3 met criteria for primary SS. All 3 individuals underwent minor salivary gland biopsy, which was diagnostic for this condition. CONCLUSIONS: These results suggest a likely association between these 2 conditions. Further epidemiological studies will be necessary to confirm this finding.