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Review Interleukin 7-induced lymphoid neogenesis in arthritis: recapitulation of a fetal developmental programme? free! 2008
Finke D, Schmutz S. · Developmental Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland. · Swiss Med Wkly. · Pubmed #18792823 links to free full text
Abstract: Chronic inflammatory diseases such as rheumatoid arthritis (RA) are associated with the de novo formation of organised lymphoid tissue in a subpopulation of patients. The aberrant expression of cytokines and chemokines by stromal cells plays an important role in recruitment and survival of effector cells of the immune system and the development of ectopic tertiary lymphoid organs (TLOs). TLOs may promote the persistence of inflammation and the recognition of self antigens. Recent studies in man and mice now indicate that interleukin 7 (IL-7) is implicated in the formation of TLOs and progression of chronic inflammation.
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