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Editorial Elucidation of the potential roles of matrix metalloproteinases in skeletal biology. free! 2003
Krane SM. · Department of Medicine, Harvard Medical School, Center for Immunology and Inflammatory Diseases, Charlestown, Massachusetts, USA. · Arthritis Res Ther. · Pubmed #12716440 links to free full text
Abstract: Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in proteolysis of joint collagens in arthritis. These approaches include identifying spontaneous genetic disorders of the enzymes and substrates in humans and animals, as well as engineering mutations in the genes that encode these proteins in mice. Insights gained from such studies can be used to design new therapies to interrupt these catabolic events.
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Review Targeting rheumatoid inflammation and joint destruction in the mouse. free! 2002
Inada M, Krane SM. · Department of Medicine, Harvard Medical School, and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts 02129, USA. · J Clin Invest. · Pubmed #12208860 links to free full text
This publication has no abstract.
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Article Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. free! 2004
Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, López-Otín C, Krane SM. · Center for Immunology and Inflammatory Diseases, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Building 149, 13th Street, Room 8301, Boston, MA 02129, USA. · Proc Natl Acad Sci U S A. · Pubmed #15563592 links to free full text
Abstract: Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. To determine the functional roles of Mmp13, we generated Mmp13-null mice that showed profound defects in growth plate cartilage with markedly increased hypertrophic domains as well as delay in endochondral ossification and formation and vascularization of primary ossification centers. Absence of Mmp13 resulted in significant interstitial collagen accumulation due, in part, to the lack of appropriate collagenase-mediated cleavage that normally occurs in growth plates and primary ossification centers. Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias. Our findings demonstrate a unique role of Mmp13 in skeletal development.
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