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Review Quality of life and quality of care for patients with gout. 2009
Singh JA. · Rheumatology Section, Medicine Service, VA Medical Center, Rheumatology (111R), One Veteran's Drive, Minneapolis, MN 55417, USA. · Curr Rheumatol Rep. · Pubmed #19296889 No free full text.
Abstract: Significant pain, activity limitation, and disability in patients with acute and chronic gouty arthritis lower health-related quality of life. Although many effective therapies are available for gouty arthritis, medication errors are common. One goal of therapy is to reduce the frequency of gout flares by lowering serum uric acid. Further, evidence suggests that the quality of care provided to patients with gout may also impact health-related quality of life. This article reviews evidence concerning quality of care and quality of life for patients with gout.
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Review Assessment of outcome in clinical trials of gout--a review of current measures. 2007
Taylor WJ, Schumacher HR, Singh JA, Grainger R, Dalbeth N. · Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, PO Box 7343, Wellington 6242, New Zealand. · Rheumatology (Oxford). · Pubmed #17650521 No free full text.
Abstract: There has been renewed interest in the treatment of gout with recent reported intervention studies of new agents such as etoricoxib, febuxostat and pegylated-uricase. However, these studies have highlighted the relative paucity of validated outcome measures with which to judge efficacy. This review outlines the published information regarding which endpoints have been measured in randomized clinical trials, what should be measured, what tools or instruments are available for this and the technical properties of such instruments. It highlights recent work that validates measures of tophi, radiographic damage and patient-reported outcomes. The absence of a valid definition of gout-flare or how flare reduction defines response is problematic; this forms the basis for a current ACR-EULAR sponsored project.
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