Primary Progressive Aphasia

Overview

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Is a:

Mental or Behavioral Dysfunction

Definition:

A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to alzheimer disease, emerges. Pathologically, there are no Alzheimer or pick disease like changes, however, spongiform changes of cortical layers ii and iii are present in the temporal lobe and frontal lobe. (From Brain 1998 Jan;121(Pt 1):115-26)

Synonyms:

Aphasia, Progressive Nonfluent
Aphasias, Primary Progressive
Aphasias, Progressive Nonfluent
Mesulam Syndrome
Mesulam's Syndrome
Nonfluent Aphasia, Progressive
Nonfluent Aphasias, Progressive
Primary Progressive Aphasia
Primary Progressive Aphasias
Progressive Aphasia, Primary
Progressive Aphasias, Primary
Progressive Nonfluent Aphasia
Progressive Nonfluent Aphasias
Syndrome, Mesulam
Syndrome, Mesulam's

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