Alzheimer Disease: Wallesch CW

Wallesch CW. · No affiliation provided · Fortschr Neurol Psychiatr. · Pubmed #18058677 No free full text.

This publication has no abstract.

Wallesch CW. · No affiliation provided · Fortschr Neurol Psychiatr. · Pubmed #15806435 No free full text.

This publication has no abstract.

Wallesch CW, Ebert AD. · No affiliation provided · Fortschr Neurol Psychiatr. · Pubmed #15472778 No free full text.

This publication has no abstract.

Wolf SA, Henry M, Deike R, Ebert AD, Wallesch CW. · Sektion Neuropsychologie der Klinik für Neurologie, Universitätsklinikum, Leipziger Strasse 44, 39120, Magdeburg, Deutschland. · Nervenarzt. · Pubmed #18040655 No free full text.

Abstract: BACKGROUND: Incipient Alzheimer's disease (AD) is frequently suspected by neurologists and psychiatrists, but diagnosis is difficult to establish. The aim of this report was to analyse to what extent suspicion is confirmed by a comprehensive neuropsychological examination intended to distinguish different types of dementia. METHODS: Descriptive data analysis was used for investigating the differential diagnoses of 47 outpatients with suspected AD referred to a department of neuropsychology by physicians in private practice. Data analysis was based upon the NINCDS-ADRDA diagnostic criteria of AD. RESULTS: Only 38% of the outpatients examined with suspected AD met the NINCDS-ADRDA diagnostic criteria for AD or mixed dementia from a neuropsychological point of view, whereas 22% met criteria for other types of dementia. The remaining patients met criteria for distinct differential diagnoses (23%) or lacked pathological findings in neuropsychological functions (17%). CONCLUSIONS: Neuropsychology is an essential part in the differential diagnosis of mild to moderate dementias. It can aid in differential therapeutic considerations concerning the treatment of dementia, for example in selecting appropriate treatments or avoiding expensive but inappropriate ones.

Bartels C, Wallesch CW. · Universitätsklinik für Neurologie, Universitätsklinikum, Magdeburg. · Nervenarzt. · Pubmed #17340091 No free full text.

Abstract: This review presents diagnostic criteria for the different dementia syndromes and mild cognitive impairment. It is being claimed that in view of the current pharmacological interventions and after exclusion of symptomatic dementia, a controlled trial with cholinesterase inhibitors or memantine is more efficient than elaborate diagnostics. Efficiency of differential diagnosis will increase when drugs are available that specifically improve the different degenerative dementias and vascular dementia. Clinical pictures of the various dementia syndromes are briefly described.

Lins H, Wichart I, Bancher C, Wallesch CW, Jellinger KA, Rösler N. · Department of Neurology, Otto-von-Guericke-University, Magdeburg, Germany. · J Neural Transm. · Pubmed #14991454 No free full text.

Abstract: Immunoreactivities of amyloid beta peptide((1-42)) (Abeta42-IR) and total tau protein (TTIR) were measured in lumbar cerebrospinal fluid of 48 patients (12 patients in each group) with normal pressure hydrocephalus (NPH), vascular dementia (VD), Alzheimer's disease (AD), Parkinson's disease without dementia (PD) and 24 controls (CON) using sensitive and specific enzyme immunoassays. TTIR in NPH was not significantly changed compared with VD, PD and CON, while NPH-Abeta42-IR was significantly decreased compared with PD and CON. In AD, significant increases of TTIR and significant decreases of Abeta42-IR were found. Using a TTIR by Abeta42 plot, all NPH, PD, and CON samples were within the non-AD plot region. 92% of AD and VD samples were within the AD and non-AD area, respectively. We conclude that combined measurement of Abeta42-IR and TTIR contributes to the differential diagnosis of NPH vs. AD and of AD vs. VD, respectively.