Alzheimer Disease: Rasgon N

Jarvik L, LaRue A, Blacker D, Gatz M, Kawas C, McArdle JJ, Morris JC, Mortimer JA, Ringman JM, Ercoli L, Freimer N, Gokhman I, Manly JJ, Plassman BL, Rasgon N, Roberts JS, Sunderland T, Swan GE, Wolf PA, Zonderman AB. · Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA. · Alzheimer Dis Assoc Disord. · Pubmed #18317242 No free full text.

Abstract: Children of persons with Alzheimer disease (AD), as a group, face an increased risk of developing AD. Many of them, throughout their adult lives, seek input on how to reduce their chances of one day suffering their parent's fate. We examine the state of knowledge with respect to risk and protective factors for AD and recommend a research agenda with special emphasis on AD offspring.

Rasgon N, Jarvik L. · Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, USA. · J Gerontol A Biol Sci Med Sci. · Pubmed #14999034 No free full text.

Abstract: Affective disorders (ad) and Alzheimer's disease (AD) have been associated for almost a century, and various neurophysiologic factors have been implicated as common biologic markers. Yet, links between ad and AD still await elucidation. We propose that insulin resistance (IR) is one of the missing links between ad and AD. IR with hyperinsulinemia and subsequent impairment of glucose metabolism especially in ad patients may promote neurodegeneration and facilitate the onset of AD. According to our hypothesis, IR may persist even into ad remission in some patients. Persistent regional hypometabolism and vascular changes resulting from long-standing IR may lead to currently irreversible structural changes. Evidence in support of the hypothesis is reviewed and clinical implications suggested.

Jarvik LF, La Rue A, Gokhman I, Harrison T, Holt L, Steh B, Harker J, Larson S, Yaralian P, Matsuyama S, Rasgon N, Geschwind D, Freimer N, Jimenez E, Schaeffer J. · University of California, Los Angeles (UCLA), Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute and Hospital, Los Angeles, California 90095-1759, USA. · J Geriatr Psychiatry Neurol. · Pubmed #16306237 No free full text.

Abstract: The objective of this pilot study on a convenience sample of 25 offspring of Alzheimer patients (mean age 61.5 +/- 8.8 years; range, 50-82) was the early detection of neurocognitive decline. This preliminary report appears to be the first one dealing with 20-year follow-up of neurocognitive data of Alzheimer's disease (AD) children. Digit symbol (Wechsler Adult Intelligence Scale) was the only of 11 neurocognitive measures with a significant decline. And that decline between first and last testing (mean = 19.98 +/- 0.30 years) was on raw scores, not scaled scores. Neither parents' age at onset of AD nor autopsy confirmation or offspring APOE-e4 status influenced neurocognitive results. More robust data than currently available are needed to confirm the findings of this first pilot study and to determine both the trajectory of neurocognitive decline in AD and the risks of developing AD faced by children whose parent had the disease.

Rasgon N, Jarvik L. · No affiliation provided · Am J Geriatr Psychiatry. · Pubmed #16505136 No free full text.

This publication has no abstract.

Jarvik LF, Harrison TR, Holt L, Jimenez E, Larson SW, LaRue A, Matsuyama SS, Rasgon N, Schaeffer J, Steh B, Yaralian P. · No affiliation provided · J Gerontol A Biol Sci Med Sci. · Pubmed #15528781 No free full text.

This publication has no abstract.

Rasgon N, Jarvik GP, Jarvik L. · No affiliation provided · Am J Geriatr Psychiatry. · Pubmed #11739073 No free full text.

This publication has no abstract.