Alzheimer Disease: Konrat C

Pariel-Madjlessi S, Opéron C, Péquignot R, Konrat C, Léonardelli S, Belmin J. · Service de gériatrie et consultation mémoire, Hôpital Charles Foix et Faculté de médecine Pierre et Marie Curie (Université Paris VI), Ivry-sur-Seine (94). · Presse Med. · Pubmed #17628389 No free full text.

Abstract: Dementia is a deterioration in several cognitive functions that affects daily living and is observed in the absence of impaired vigilance. Dementia may be revealed by symptoms of memory loss but also by a loss of functional autonomy, onset of depression or by behavioral problems; it may also be recognized during a screening examination. Evaluation of cognitive functions is an essential stage of this diagnosis. Simple tests that any physician can perform provide a first approach. A more detailed cognitive evaluation by a specialist or neuropsychologist is then necessary (except in advanced cases). Once dementia is diagnosed, a causal investigation is required to assess its severity and extent, in order to organize management. Lack of recognition of dementia in the elderly and delay in its diagnosis raise the question of screening to detect it at an earlier stage.

Belmin J, Péquignot R, Konrat C, Pariel-Madjlessi S. · Service de gériatrie et consultation mémoire, Hôpital Charles Foix et Université Paris VI, Ivry-sur-Seine (94). · Presse Med. · Pubmed #17601697 No free full text.

Abstract: Management of Alzheimer disease is based on drug and nondrug treatments. Specific drug treatment includes acetylcholinesterase inhibitors and memantine. They show moderate efficacy superior to that of placebo for global condition, cognitive disorders, need for care, and behavioral problems, but do not prevent further decline. These treatments remain underused. The efficacy of psychotropic drugs (antidepressants, neuroleptics, and antipsychotic agents) in treating behavioral problems is not well documented. Nondrug activities and interventions have not been sufficiently evaluated scientifically. These involve interventions against the consequences of the disease (loss of autonomy, malnutrition) and helping patients' family caregivers. Among these activities, the best evaluated and most interesting are: educational programs for caregivers, occupational therapy at home, and interventions at home by nurses specially trained as case managers.