Alzheimer Disease: Brandt C

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A digest of articles written 1999 and later, on the topic "Alzheimer Disease," originating from Planet Earth —» Brandt C.  Display:  All Citations ·  All Abstracts
1 Article Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic. 2008

Brandt C, Bahl JC, Heegaard NH, Waldemar G, Johannsen P. · Memory Clinic, Section 6702, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. · Dement Geriatr Cogn Disord. · Pubmed #18536519 No free full text.

Abstract: AIM: Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory clinic. METHODS: 147 consecutive patients with a lumbar puncture as a part of their clinical workup were studied. A retrospective diagnosis was established based on consensus criteria without the knowledge of the CSF results. RESULTS: When diagnosing Alzheimer's disease (AD) compared to other diagnoses, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity. CONCLUSION: In a tertiary setting, abnormal CSF biomarker results may be of a diagnostic value - whereas normal results do not exclude neurodegenerative disease.

2 Article Challenges of implementing intervention research in persons with dementia: example of a glider swing intervention. 2001

Snyder M, Tseng YH, Brandt C, Croghan C, Hanson S, Constantine R, Kirby L. · School of Nursing, University of Minnesota, Minneapolis, Minnesota, USA. · Am J Alzheimers Dis Other Demen. · Pubmed #11416948 No free full text.

Abstract: Intervention studies for persons with dementia present many challenges. This article describes challenges encountered in conducting a glider swing intervention study for persons with dementia and the strategies used to manage the problems encountered. The overall purpose of a quasi-experimental study was to explore the effects of a glider swing intervention on emotions, relaxation, and aggressive behaviors in nursing home residents with dementia. Suggestions for investigators conducting intervention studies for persons with dementia are provided.