Alzheimer Disease: Ashery U

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A digest of articles written 1999 and later, on the topic "Alzheimer Disease," originating from Planet Earth —» Ashery U.  Display:  All Citations ·  All Abstracts
1 Review No more brain tangles with DeltaNp73. free! 2009

Mattson MP, Ashery U. · Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. · Trends Biochem Sci. · Pubmed #19008105 links to  free full text

Abstract: In Alzheimer's disease (AD), neurons suffer dysfunction and death associated with aberrant tau phosphorylation and subsequent neurofibrillary tangles. A new study reveals a surprising neuroprotective role for a truncated p73 isoform (DeltaNp73). Aged mice with reduced DeltaNp73 levels exhibit tau pathology and cognitive deficits, and DeltaNp73 reduction in mice with amyloid pathology causes extensive tangle formation and neuron death. These findings provide a novel animal model of AD and a potential therapeutic role for DeltaNp73 inducers.